All news from Anaesthesiology

Big Let-up In Obamacare Premiums

Millions of people covered under the Affordable Care Act will see only modest premium increases next year, and some will get a price cut. That is the conclusion from an exclusive analysis of the besieged but resilient program, which still sparks deep divisions heading into this year's midterm elections.

Methylation Of Enzymes Within Peptide Bonds

While chemical methylation of an amide bond uses a strong base to generate the imidate, OphA, the precursor protein of the fungal peptide macrocycle omphalotin A, self-hypermethylates amides at pH 7 using S-adenosyl methionine (SAM) as cofactor.

The peptide bond, the defining feature of proteins, governs peptide chemistry by abolishing nucleophilicity of the nitrogen. This and the planarity of the peptide bond arise from the delocalization of the lone pair of electrons on the nitrogen atom into the adjacent carbonyl.

End-of-Life Decision To Seek Advance Care

Former first lady Barbara Bush died on April 17 at the age of 92 in her home in Houston, Texas after making the decision to seek advanced care directive home care hospice, or comfort care, for her terminal illness.

The respected and beloved first lady was suffering from congestive heart failure and chronic obstructive pulmonary disease, and had decided a couple of days prior to her passing that she would “not seek additional medical treatment and will focus on comfort care.