All news from Anaesthesiology

Human Heart Muscle Grown from Patient-Specific Stem Cells

Columbia biomedical engineers grow first human heart muscle from stem cells that show critical hallmarks of adult human heart function, in just four weeks. Growing human cardiac tissue that behaves like native heart muscle would be transformative for biomedical research, enabling researchers to study human physiology and model heart diseases under fully controlled conditions.

While today scientists can grow many tissues, including the heart muscle, from stem cells taken from a small blood sample of any of us, current bioengineered tissues fail to show some of the most critical hallmarks of adult human heart function.

Researchers have not been able to build a cultured heart muscle mature enough to be useful for medical research until now. The study was published today in Nature

Enzyme Plays Role In Cancer Development

In a new study, researchers have discovered how an enzyme that plays a key role in cancer development functions. The researchers hope the new knowledge will lead to the design of more precise drugs.

Researchers at the University of Copenhagen have come closer to understanding how an enzyme that appears to be important to cancer development behaves inside the cells. The new study, published in the scientific journal Nature Communications, shows first of all that the enzyme METTL13 helps control the formation of new proteins in the cells.

Relationship Between Vasoactive Medication Use And The Outcome Of ICU-Acquired Weakness

At least 25% of critically ill patients who receive mechanical ventilation in intensive care units (ICUs) develop muscular weakness severe enough to impair their quality of life. The study was published in the journal Chest.

They designed to investigate possible causes, researchers found that mechanically ventilated patients treated with vasopressor medications had a more than three-fold increase in the odds of developing ICU-associated weakness. These findings highlight the unintended adverse effects of treatment and suggest possible interventions or avoidance strategies.

Astronauts Really Suffer In Space From Radiation

In space, there are no breathable air, microgravity wastes away your bones and muscles and you’re subjected to increased doses of radiation in the form of high-energy charged particles. Space is a really inhospitable place to live there is no breathable air, microgravity wastes away your bones and muscles and you’re subjected to increased doses of radiation in the form of high-energy charged particles. These can cause damage to the cells in your body by breaking up the atoms and molecules that they’re made of.

Air flow In The Human Upper Airway Using In-vitro Models

A better understanding of airflow characteristics in the upper airway (UA) is crucial in investigating obstructive sleep apnea (OSA), particle sedimentation, drug delivery, and many biomedical problems. Direct visualization of airflow patterns in in-vitro models with realistic anatomical structures is a big challenge.

In this study, we constructed unique half-side transparent physical models of normal UA based on realistic anatomical structures. A smoke-wire method was developed to visualize the airflow in UA models directly.

The results revealed that the airflow through the pharynx was laminar but not turbulent under normal inspiration, which suggested that compared with turbulent models, a laminar model should be more suitable in numerical simulations. The flow predicted numerically using the laminar model was consistent with the observations in the physical models.