All news from Anaesthesiology

Enhancing Clinical Study Design and Generate Real-world Evidence

PAREXEL International Corporation, a leading innovator of global biopharmaceutical services, and Datavant, Inc., a healthcare technology company focused on enabling the secure de-identification and linking of healthcare datasets, today announced they are partnering to enhance clinical study design and operations, as well as the generation of real-world evidence.

As part of PAREXEL's focus on providing innovative scientific and clinical data strategies, the collaboration will enable the linking of healthcare data from a variety of real-world and clinical study data sources to improve drug development and commercialization processes.

Stem Cells Can Make New Cartilage And Repair Damaged joints

Researchers have identified stem cells that can make new cartilage and repair damaged joints. The cells reside within the temporomandibular joint (TMJ), which articulates the jaw bone to the skull. When the stem cells were manipulated in animals with TMJ degeneration, the cells repaired cartilage in the joint.

A single cell transplanted in a mouse spontaneously generated cartilage and bone and even began to form a bone marrow niche. The study was published in Nature Communications.

Human Lung Development: Researchers Grow Stem Cell-derived Lung Organoids

Researchers have now grown lung organoids from human embryonic stem cells (hESCs) that, after implantation in mice, can develop mature alveolar type 1 (AT1) and AT2 cells and architecture approximating that of human lungs. The strategy is the first to generate both lung distal progenitor cells and mature AT1-like cells. The study is published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.