Topical retinoids, which target retinoic acid receptors, are commonly used to treat acne. New research published in the British Journal of Dermatology reveals that trifarotene, a fourth-generation retinoid with potent and selective activity against only one particular retinoic acid receptor, may have an improved efficacy and safety profile compared with less selective retinoids. To characterize the in vitro metabolism and the pharmacology of the novel retinoid trifarotene.
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About one person out of 500 has a heart condition known as hypertrophic cardiomyopathy (HCM). This condition causes thickening of the heart muscle and results in defects in the heart's electrical system. Under conditions of environmental stress such as exercise, HCM can result in sudden death. In other cases, patients may go undiagnosed, with their heart function declining gradually over decades. The study, published in Nature Biomedical Engineering
By using a larval zebrafish model, Dr. Du Jiulin's lab at the the Institute of Neuroscience and Zunyi Medical College revealed that two commonly used intravenous anesthetic drugs, propofol and etomidate, suppress the excitability of locus coeruleus neurons via synergic mechanisms thus inhibiting presynaptic excitatory inputs and inducing membrane hyperpolarization of these cells.
The hospice in Owen Sound is like most others in Canada appear to be they don’t perform assisted deaths, the president of the provincial association representing the hospice palliative care sector said Thursday. The issue was raised by Owen Sound resident Bob Hope. He questioned why the hospice in Owen Sound doesn’t allow assisted deaths there.
Alex Hector is a former board member and now executive director of Residential Hospice of Grey-Bruce Inc., which runs Chapman House hospice in Owen Sound. He and a board member, Dr. Hazel Lynn, said in interviews Thursday the board’s decision in 2016 and now not to allow assisted deaths but to facilitate them elsewhere when requested is philosophical.
Patients with severe traumatic brain injury treated at Helsinki University Hospital, Finland, recover to functional independence more often than before. At the same time, the proportions of elderly patients and patients treated conservatively have increased.
The study found no specific reason to explain the observed improvement in outcomes; the results are accounted for by improvements in performance and effectiveness throughout the treatment chain, researchers say.
According to a study, researchers examine premature birth alters the balance of interneurons in the cerebral cortex that can be restored with estrogen treatment. The study was published in JNeurosci.
The two most widely used techniques used by paramedics to support a patient's breathing during cardiac arrest are similarly effective, a major new clinical trial has revealed. A two-year study involving more than 9,000 patients and 1,500 paramedics found the use of a modern device to provide advanced rescue breathing during cardiac arrest achieved a similar survival rate to the existing more complex technique.
Researchers focused on outcomes for adult patients 30 days after they received artificial ventilation during a resuscitation attempt for cardiac arrest outside the hospital. The findings of the study were published today in the Journal of the American Medical Association (JAMA).
Positive And Balancing Selection Associated With Psychiatric Disorders And Human?Unique Personality Traits
Research has revealed the evolution of a gene related to such human-unique psychiatric traits. Human-unique characteristics such as highly social behavior, languages and complex culture have evolved is a long-standing question.
For high-risk patients with implantable cardioverter-defibrillators (ICDs), ranolazine does not significantly reduce the risk of ventricular tachycardia (VT) or ventricular fibrillation (VF) requiring appropriate ICD therapy, or death. The study was published in the Journal of the American College of Cardiology. Researchers randomized high-risk ICD patients with ischemic or nonischemic cardiomyopathy to 1,000 mg ranolazine twice daily (510 patients) or placebo (502 patients).
The timing of epileptic seizures may be linked to natural circadian rhythms, which may help to guide future treatment options, new research suggests. In what is believed to be the largest study of individual patients' seizure cycles, researchers found that most seizures followed a circadian rhythm.
Some patients experienced weekly and 3-weekly seizure cycles, and some had a combination of daily, weekly, or longer cycles associated with their seizures. This will help guide therapy, and may ultimately allow more tailored therapies to be provided," Cook said. The study was published in Lancet Neurology.
Concussion symptoms for children under 13 years old typically last three times longer than they do for older teens and adults, but keeping them out of the classroom during recovery is not necessarily the preferred treatment, according to a comprehensive research review in The Journal of the American Osteopathic Association.
On 11 September 2018, HealthMap noted a news- media report of a mystery disease in Kanchanrup Municipality of Saptari in Nepal. The original report specified 3 deaths and 400 affected, presenting with high fever, cough, joint pain, headache, and muscle cramps within the last 15 days of the report.
More information on the source of illness, other symptoms, confirmation of case count, and disease identification were sought through the EpiCore system’s Request for Information (RFI).