Issued in conjunction with The Michael J. Fox Foundation, important consensus guidelines for running proof of concept preclinical and clinical trials of drugs targeting alpha-synuclein to slow or arrest the progression of the disease published in the Journal of Parkinson's Disease.
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Micropores in fabricated tissues such as bone and cartilage allow nutrient and oxygen diffusion into the core, and this novel approach may eventually allow lab-grown tissue to contain blood vessels, according to a team of Penn State researchers.
Antibodies and their derivatives radiolabelled with positron and gamma emitting radiometals enable sensitive and quantitative molecular Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) imaging of antibody distribution in vivo.
A team of researchers from the Singapore University of Technology and Design (SUTD) and Nanyang Technological University (NTU) have developed novel ferrocene-based molecules that impair the malaria parasite's metabolic function leading to parasite death.
Pregnant women and the extremely obese are among those at high risk for complications from the flu including death – and should be tested and begin antiviral treatment promptly if they are sick enough to be hospitalized with flu symptoms, according to updated guidelines released by the Infectious Diseases Society of America (IDSA).
FGD4 (Frabin) is an F-actin binding protein with GTP / GDP exchange activity specific for CDC42 . It is involved in the reorganization of the cytoskeleton act, which requires both actin binding and CDC42 activating function of FGD4. Expression of FGD4 is altered in patients with different hereditary motor and sensory neuropathies as a result of demyelination of neurons.
Patients with chronic Essex-Lopresti injuries who underwent interosseous membrane reconstruction with a bone-patellar tendon-bone graft combined with ulnar shortening osteotomy experienced satisfactory clinical and functional results, according to findings published in the Journal of Bone and Joint Surgery.
A weekly full-body massage may be an effective way to help patients with knee osteoarthritis (OA) manage pain, data from a randomized trial show.
Research completed at Johns Hopkins and the Greater Baltimore Medical Center has demonstrated that vaginal childbirth substantially increases the probability a woman will develop a pelvic floor disorder later in life. Pelvic floor disorders, including urinary incontinence and uterine prolapse, afflict millions of women in the United States.
An estimated 45 million Americans wear contact lenses. Improper care or wear, like going to sleep without removing your glasses, can lead to infections of the cornea like microbial keratitis, which can lead to serious health problems.
The World Health Organization (WHO) is creating a global panel to study human gene editing and the scientific, legal, social, and ethical challenges that surround it so the organization may move toward standards for oversight and governance.
HHS issued new guidance today that recommends prescribing or co-prescribing naloxone and providing education about this treatment in patients at high risk for opioid overdose, according to a press release.