All news from Anaesthesiology

Ethicon Demonstrates Life-Changing Obesity Treatment

Ethicon, part of Johnson & Johnson Medical Devices Companies (JJMD), demonstrates its commitment to improving access to life-changing obesity treatment and putting the most appropriate surgical tools in surgeons hands at the 23rd World Congress of the International Federation for the Surgery of Obesity and Metabolic Diseases (IFSO 2018).

Structure Of The Human Epithelial Sodium Channel By Cryo-EM

New research for the first time reveals the three-dimensional structure of a membrane channel that's critical in controlling blood pressure. The findings represent the first time the human epithelial sodium channel has been shown so precisely since it was first isolated and described through expression cloning more than two decades ago.

The breakthrough could lead to 'new and better treatments blood pressure medications. The study was published in the journal eLife.

Diseased Heart Muscle Cells Have Short Telomeres

Researchers say the finding could lead to new pathways for drug discovery. People with cardiomyopathy have abnormally short telomeres in the muscles that contract the heart. A telomere is a DNA sequence that serves as a protective cap on the ends of chromosomes.

A previous study showing that people with Duchenne muscular dystrophy, a genetic muscle-wasting disease, also have short telomeres in their heart muscle cells or cardiomyocytes. These patients often die at an early age from heart failure. The study was published in the Proceedings of the National Academy of Sciences.

Chaperones Convert The Energy Into The Nonequilibrium Stabilization Of Native Proteins

Chaperones are specialized proteins in the cell that help other proteins to reach their functional 3D shapes, which correspond to the states preferred at thermodynamic equilibrium. But a new study by EPFL, UNIL and INSERM (France) scientists shows that chaperones can also maintain proteins in non-equilibrium states, potentially altering their fate. The study was published in Nature Chemical Biology.

Sedation Is Unnecessary For Colonoscopy

Deep sedation for routine colonoscopy is of marginal benefit, costs more and may negatively affect safety and quality compared with mild-to-moderate sedation with traditional sedatives. The increasing use of deep sedation for colonoscopy in North America is a trend that should be curtailed to reduce unnecessary spending associated with procedures, and needless intervention that may cause harm.

In many countries, a large proportion of colonoscopies are performed with little or no sedation. According to a national audit in the United Kingdom, 0.4% of colonoscopies were performed using propofol, a short-acting drug that induces a state of deep sedation, and 10.7% were performed without sedation.