All news from Medical Toxicology

Birth Mode Effects on Neurodevelopment, Findings

Cesarean-born mice show altered patterns of cell death across the brain, exhibiting a greater nerve cell death than vaginally delivered mice in at least one brain area, a finding by Georgia State University that suggests that it may have effects on human neurodevelopment that may lead to long-lasting changes in the brain and behavior.

Human Cells can Dissolve Damaging Protein Aggregates

The formation of protein complexes is a highly organized process that does not begin with the "finished" proteins. Researchers demonstrate that they form in a coordinated way when the protein subunits are synthesized.

Our findings fundamentally alter our understanding of how biologically active protein complexes form in the cell. The study was published in  Nature 

Biosensor Advances Diverse High-level Production of Microbial Cell Factories

A research group presented a novel biosensor which can produce diverse, high-level microbial cell factories. The biosensor monitors the concentration of products and even intermediates when new strains are being developed. This strategy provides a new platform for manufacturing diverse natural products from renewable resources. The team succeeded in creating four natural products of high-level pharmaceutical importance with this strategy.

Obesity: Combating with Community-Based Approaches

The EU faces alarming increases in obesity and associated health problems such as cardiovascular disease, cancer and diabetes. Worldwide, some 10 % of people are excessively overweight and obesity is on track to overtake smoking as the single biggest cause of preventable cancer in some countries. The issue is complex and rooted in the inactive nature of modern life characterized by extensive car use and widely available, affordable, and often unhealthy food.

Biological Applications of Titanium Nanoparticles

Titanium nanoparticles are nano-sized particles (1-100 nm) made of titanium dioxide (TiO 2 ). They are cheap to produce and have applications in optics, materials science, electronics, catalysis, as a pigment, and in biology.

Titanium nanoparticles in artificial joints

The serviceable life of artificial joints such as hips or knees, usually around fifteen years before replacement is required, can be greatly extended using titanium nanoparticles. The nanoparticles are used to coat the artificial joint and provide a hard, resistant surface with improved resistance to wear.

Similarly, other implants can be coated in this way to improve biocompatibility and lessen the risk of bacterial infections.

Lyme Disease Bacteria: New Techniques Developed for Faster Detection

Researchers have developed techniques to detect Lyme disease bacteria weeks sooner than current tests, allowing patients to start treatment earlier. The findings appear in the journal Clinical Infectious Diseases. The authors include scientists from Rutgers Biomedical and Health Sciences, Harvard University, Yale University, the National Institute of Allergy and Infectious Diseases, FDA, Centers for Disease Control and Prevention, and other institutions.