Researchers have developed designer molecules that may one day be able to seek out and trap deadly nerve agents and other toxic compounds in the environment – and possibly in humans.
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New research highlights a more accurate way to screen for preeclampsia in pregnant women than currently recommended methods. Published early online in Ultrasound in Obstetrics & Gynecology, the study challenges the UK's current guidelines on the management of hypertensive disorders during pregnancy.
A new study led by investigators at Brigham and Women's Hospital and Harvard THR Chan School of Public Health is the first to look at the results of the black men and to whether an optimized screening strategy with baseline prostate-specific antigen (PSA) levels predict prostate cancer in this population
A new study evaluates important aspects of psychological health in young adults with kidney failure. The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), point to the need for additional efforts to address the wellbeing of these patients
According to recent research, endurance exercise training beneficially modifies gut microbiota composition. After six weeks of training, potentially inflammation causing microbes (Proteobacteria) decreased and microbes that are linked to enhanced metabolism (Akkermansia) increased.
Mistakes in "proofreading" the genetic code of retinal cells is the cause of a form of inherited blindness, retinitis pigmentosa (RP) caused by mutations in splicing factors. This new understanding of the disease process, published in Nature Communications, is leading to the development of a gene therapy for RP caused by splicing factor defects.
Cesarean-born mice show altered patterns of cell death across the brain, exhibiting a greater nerve cell death than vaginally delivered mice in at least one brain area, a finding by Georgia State University that suggests that it may have effects on human neurodevelopment that may lead to long-lasting changes in the brain and behavior.
The formation of protein complexes is a highly organized process that does not begin with the "finished" proteins. Researchers demonstrate that they form in a coordinated way when the protein subunits are synthesized.
Our findings fundamentally alter our understanding of how biologically active protein complexes form in the cell. The study was published in Nature
A research group presented a novel biosensor which can produce diverse, high-level microbial cell factories. The biosensor monitors the concentration of products and even intermediates when new strains are being developed. This strategy provides a new platform for manufacturing diverse natural products from renewable resources. The team succeeded in creating four natural products of high-level pharmaceutical importance with this strategy.
The EU faces alarming increases in obesity and associated health problems such as cardiovascular disease, cancer and diabetes. Worldwide, some 10 % of people are excessively overweight and obesity is on track to overtake smoking as the single biggest cause of preventable cancer in some countries. The issue is complex and rooted in the inactive nature of modern life characterized by extensive car use and widely available, affordable, and often unhealthy food.
Titanium nanoparticles are nano-sized particles (1-100 nm) made of titanium dioxide (TiO 2 ). They are cheap to produce and have applications in optics, materials science, electronics, catalysis, as a pigment, and in biology.
Titanium nanoparticles in artificial joints
The serviceable life of artificial joints such as hips or knees, usually around fifteen years before replacement is required, can be greatly extended using titanium nanoparticles. The nanoparticles are used to coat the artificial joint and provide a hard, resistant surface with improved resistance to wear.
Similarly, other implants can be coated in this way to improve biocompatibility and lessen the risk of bacterial infections.
Researchers have developed techniques to detect Lyme disease bacteria weeks sooner than current tests, allowing patients to start treatment earlier. The findings appear in the journal Clinical Infectious Diseases. The authors include scientists from Rutgers Biomedical and Health Sciences, Harvard University, Yale University, the National Institute of Allergy and Infectious Diseases, FDA, Centers for Disease Control and Prevention, and other institutions.