All news from Trauma and Critical Care Medicine

Prevalence & Nature of Financial Considerations In ICU

Among patients in the intensive care unit (ICU), 4.2% of admissions have at least one note reflecting financial considerations. The study was published in JAMA Network Open.  

Researchers characterized the prevalence and nature of financial considerations documented in narrative clinical records. Data were analyzed from individuals hospitalized from June 1, 2001, to Oct. 31, 2012; 46,146 index ICU admissions were included.

New Clinical Practice For Moderate To Severe Traumatic Brain Injury

Millions of children and teens are affected by sports and recreation-related traumatic brain injuries (TBI) annually. To help reduce the effects of TBIs in youth sports, all 50 states and the District of Columbia enacted state youth TBI laws between 2009 and 2014.

A new study from the Center for Injury Research and Policy at Nationwide Children's Hospital examined the effectiveness of these laws by looking at sports and recreation mild TBI (mTBI) -related emergency department (ED) visits for children ages 5 to 18 years before and after TBI legislation was enacted in each state.

Specifically, the researchers looked at the EDI visits from 2006 through 2014 for diagnosis of mTBI and compared them with diagnoses of moderate to severe TBI, minor head injury, and long bone fracture. The study was published in the Journal of Head Trauma and Rehabilitation.

Association Between Sleep Disruptions And Brain Disorders

Sleep disruptions are associated with many brain disorders, including anxiety, dementias, and traumatic brain injury. While these disruptions are sometimes seen as a side effect of brain disorders.

New findings presented today suggest that aberrant sleep-wake cycles can also drive brain pathology. The studies were presented at Neuroscience 2018, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.

New Target To Inhibit Progression of Liver Disease

Naglaa Shoukry, Ph. D., and her team have made a significant breakthrough in their research aiming to limit the progression of liver disease. They have characterized the mechanisms of action of type 3 inflammatory cytokines that are produced by the cells of the immune system, which result in a progression of hepatic scarring known as fibrosis. 

Fish-Enriched Diet Reduce Childhood Asthma

A study led by La Trobe University has shown that eating fish such as sardines, salmon and trout twice a week can reduce asthma symptoms in children. The international clinical trial found that children who ate the fatty fish as part of a healthy Mediterranean diet had improved lung function after six months.

BH3 Mimetics Induce Apoptosis Independent Of DRP-1 In Melanoma

Think of the protein BH3 like a finger that turns off to cancer cell survival switch. The problem is that most cancer cells have found ways to remove this "finger commonly, by breaking the action of a gene called p53 that puts the BH3 finger in motion.

Now think of Bcl-2 as the switch itself. When cancer breaks p53, the BH3 finger never moves, and the Bcl-2 survival switch remains on. Despite thousands of published studies, researchers have not had much luck directly protecting the action of p53. But, BH3 is another story.

The study was published in the journal Cell Death and Disease.

Defensive ICD Programming Is Safe & Reduces Inappropriate Therapy

Sudden cardiac death is a common cause of death in patients with congenital or acquired heart disease. An implanted cardiac defibrillator (ICD) can effectively put a stop to any underlying cardiac arrhythmia. In a long-term observational study involving 1,500 patients.

Researchers have shown that the progress selected for the implanted defibrillators (ICDs) plays a major role. It was found that the most "defensive" possible procedure is safe and, at the same time, significantly reduces inappropriate therapy.

The study was published in Circulation.