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Mechanisms Of Heat-Resistant Enzymes For Drugs

A recent study looked at one of the most essential enzymes in medicine to aid better, and more cost-effective design of drugs. The mechanisms and actions of heat-resistant enzymes are being investigated to aid better, more cost-effective drug design. 

The research was co-authored by Dr. Nitin Jain, UT Biochemistry and Cellular and Molecular Biology Associate Professor, and graduate student Sara Lemmonds. It is focused on Cytochrome P450, an enzyme that occurs naturally in the body and other environments, and one that is critical in metabolizing over 90% of pharmaceutical drugs.

The study was published in the Proceedings of the National Academy of Sciences.

Ketamine Used For Depression Treatment

It was an anesthetic for animals and people became a potent battlefield pain reliever in Vietnam and morphed into the trippy club drug Special K. Now the chameleon drug ketamine is finding new life as an unapproved treatment for depression and suicidal behavior.

Clinics have opened around the United States promising instant relief with their "unique" doses of ketamine in IVs, sprays or pills. And desperate patients are shelling out thousands of dollars for treatment often not covered by health insurance, with scant evidence on long-term benefits and risks.

Chicago preschool teacher Lauren Pestikas long struggled with depression and anxiety and several suicide attempts before trying ketamine earlier this year. The price tag is about $ 3,000, but "it's worth every dollar and penny," said the 36-year-old.