All news from Transfusion Medicine

Rise in Cardiovascular Diseases Rates in Nepal

Cardiovascular disease in Nepal will account for 35 percent of all the deaths in the country by 2030! Currently, the Himalayan nation is facing threat from cardiovascular diseases which accounts to one death in every hour. Eminent Interventional Cardiologist Dr Rajneesh Kapoor visited Kathmandu for a workshop about ‘complex cardiac procedures’ on November 4, 2018.

HIV in Cancer Patients: Immunotherapy is Safe and Feasible

Immunotherapy has been a major breakthrough in oncology, with registered drugs now approved for use in an increasing number of tumour types – but little is known about its safety for HIV-positive cancer patients. A study (1) to be presented at the ESMO 2018 Congress in Munich has now provided data to suggest that treatment with PD-1/PD-L-1 immune checkpoint inhibitors, which target the very system affected by the HIV virus, is feasible in this patient population for whom cancer is currently one of the principal cause of mortality.

Fungal Diversity: Expansion by One Cell at a Time

Researchers have developed a pipeline to generate genomes from single cells of uncultivated fungi. The approach was tested on several uncultivated fungal species representing early diverging fungi, the earliest evolutionary branches in the fungal genealogy that provide a repertoire of important and valuable gene products.

Invasive Property of Breast Cancer Cells Identified

Researchers from Karolinska Institutet in Sweden have identified a protein that determines the identity and invasive properties of breast cancer cells. The finding could lead to the development of new therapeutic and diagnostic strategies to target breast cancer invasion and metastasis. The study is published in the scientific journal Cancer Research.

RSV Infection Prevention by Delivering Antibodies via mRNA

Almost every child gets respiratory syncytial virus (RSV), which causes cold-like symptoms. It's usually a big deal if they're healthy, but every year in the US some 57,000 children under the age of five are hospitalized with the infection. To make matters worse, there is no vaccine and sometimes used to prevent RSV in high-risk children is not always effective. Now researchers at the Georgia Institute of Technology have developed a promising method of delivering antibodies directly to the lungs, improving their effectiveness in warding off RSV.

Malaria Detection by Sniffer Dogs, Findings

Dogs could be trained to sniff out malaria in people according to new research aimed at preventing the spread of the deadly disease. Researchers found that dogs could scent malaria in samples of socks worn by infected children. They say their findings could potentially lead to the first rapid and non-invasive test for malaria.

Shorter Therapy for Pulmonary Tuberculosis, Study Findings

Almost half of the nearly 10 million patients with active tuberculosis each year could have been cured with lesser treatments than current guidelines, UC San Francisco has found. The results suggest targeted therapies could be more effective in treating TB, which killed an estimated 1.3 million people around the world last year.

Cystic Fibrosis: Patients May Receive Insufficient Antibiotics to Fight Lung Infections

The majority of patients with cystic fibrosis may not achieve blood concentrations of antibiotics sufficiently high enough to effectively fight bacteria responsible for pulmonary exacerbations, leading to worsening pulmonary function, indicates a study led by researchers. Additionally, the study findings show that it's impossible to predict solely from dosing regimens which patients will achieve therapeutically meaningful antibiotic concentrations in their blood.