For more than 3 million people around the world, kidney failure is a life-altering diagnosis, if not a life-threatening one. While about 17 percent of people in the U.S. with end-stage kidney disease are now getting transplants, the average time spent waiting is 3-5 years. And much of that time is consumed by planning for, receiving and recovering from treatment
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People with type 1 diabetes who use marijuana may double their risk of developing a life-threatening complication, a new study suggests. Called diabetic ketoacidosis (DKA), the condition occurs when there is not enough insulin to break sugar in the body, so the body burns fat for fuel instead. This triggers a build-up of chemicals known as ketones, which make blood more acidic and can lead to coma or death
A new model created by UCLA scientists reveals how the alteration of a specific gene increases the risk for neurodevelopmental problems in mice. When the researchers mutated the gene, it produced symptoms at specific ages in the animal's life
Ninety-one nations are not producing enough children to maintain their current populations, while the opposite is true in 104 countries where high birth rates are driving population increases, according to a new scientific study
Cell-penetrating peptides (CPPs) have attracted great interest as delivery vehicles in medicine, with potential for the development of novel therapeutic agents or cosmetic products. Biological membranes are typically waterproof to almost all compounds with a molecular weight greater than 500 Da.
Researchers have developed a way to grow human heart tissue that can serve as a model for the upper chambers of the heart, known as the atria. The tissue, derived from human induced pluripotent stem cells (hiPCSs), beats, expresses genes, and responds to drugs in a similar manner to a real human atrium. The model may be useful for evaluating disease mechanisms and drugs for atrial fibrillation – the most common type of arrhythmia.
A small device that contains human cells in a 3D matrix represents a giant leap in the ability of scientists to test how those cells respond to stresses, drugs and genetic changes. About the size of a thumb drive, the devices are known as tissue chips or organs on chips.
Scientists report that Hsp70s from mammalian cells behave quite differently from bacterial Hsp70s. Because of the important roles Hsp70s play in protein misfolding diseases such as cancer and neurodegenerative diseases, the new findings 'will have a major impact on how we think about Hsp70s,' one of the researchers says. The study appears in PNAS.
New research has linked adolescent obesity with up to a four-fold increased risk of pancreatic cancer later in life. The study's results also suggest that overweight and even higher weight within the "normal" weight range in men may increase pancreatic cancer risk in a graded manner.
Explaining consciousness is one of the hardest problems in science and philosophy. Recent neuroscientific discoveries suggest that a solution could be within reach – but grasping it will mean rethinking some familiar ideas. Consciousness, I argue in a new paper, may be caused by the way the brain generates loops of energetic feedback, similar to the video feedback that "blossoms" when a video camera is pointed at its own output.