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OSA Patients: Slow-Release Morphine May Be Safe for Some

A 40-mg dose of slow-release morphine may be safe for non-severely obese patients with obstructive sleep apnea (OSA), researchers in Australia report.  "Slow-release morphine did not seem to be the OSA of the men in our study." For most of the men, there were no differences in breathing during sleep whether they received oral 40-mg slow-release morphine or placebo, "said Dr. David Wang. 

Cholera Epidemics In Yemen: Lack of Preparedness and Insecurity Hampered Response

Between April 27, 2017 and July 1, 2018, more than one million suspected cases of cholera in two waves were reported in Yemen, which had been declared a high-level emergency by the United Nations in 2015. Humanitarian organizations implemented a robust response to cholera despite numerous challenges including famine-like conditions, active civil conflict and destroyed health infrastructure within a shrinking humanitarian space in Yemen.

PADN-5: Ablation Reduces Pulmonary Hypertension in HF

Patients with combined pre and postcapillary  pulmonary hypertension  (CpcPH) secondary to left-sided  heart failure  (HF) who underwent a pulmonary artery denervation (PADN) procedure had significant improvements in hemodynamic and clinical outcomes at 6 months, compared with patients who underwent a sham procedure, in the PADN-5 trial.

Enzyme's Unfrozen Adventure: In Crystallo Protein Thermodynamics

Researchers a have reported the first in crystallo thermodynamic analysis of copper amine oxidase catalysis using a non-cryocooled technique. The method, which analyzes protein crystals coated with a water-soluble polymer, rather than cryogenically cooled crystals, can be temperature-controlled, allowing for conformational changes to be monitored over a range of temperatures. Additionally, the conditions show parallels with the cytosol, meaning that the approach could provide a useful model for protein behavior in cells.