A single season of high school football may cause microscopic changes in the structure of the brain, according to a new study. A new type of magnetic resonance imaging (MRI) revealed significant changes in the structure of the gray matter in the front and rear of the brain and changes to structures deep inside the brain. The study is published in Neurobiology of Disease. ?
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Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure. A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy (ART) originated from cellular proliferation, not viral replication, according to new research published in Nature Communications.
Lowering mutation rates in harmful bacteria might be an as yet untried way to hinder the emergence of antimicrobial pathogens. One target for drug development might be a protein factor, DNA translocase Mfd, which enables bacteria to evolve rapidly by promoting mutations in many different bacterial species.
This action speeds antibiotic resistance, including multi-drug resistance. Working on drugs to block Mfd and similar factors could be a revolutionary strategy to address the worldwide crisis of treatment-resistant infectious diseases.
A South American tribe living in near-total isolation with no Western dietary influences showed no increase in average blood pressure from age one to age 60, according to a study led by Johns Hopkins Bloomberg School of Public Health. In comparison, a nearby tribe whose diet includes some processed foods and salt did show higher blood pressure into late middle age
Age-related declines in abstract reasoning ability predict increasing depressive symptoms in subsequent years, according to longitudinal data of older adults in Scotland. The research is published in Psychological Science , a journal of the Association for Psychological Science
Nearly 6 million Americans are living with Alzheimer's disease , and that number is expected to increase to nearly 14 million by 2050. Aside from the disease's burden to the patient, it's also a family caregivers. According to the Alzheimer's Association, 16.1 million Americans provide unpaid care for people with Alzheimer's or other dementias , accounting for an estimated 18.4 billion hours of care
Hot water treatment may help improve inflammation and blood sugar (glucose) levels in people who are unable to exercise, according to a new study. The findings are published ahead of print in the Journal of Applied Physiology
A study of Japanese people living in Malaysia found that their exercise routines affected time spent sitting down and quality of life, including their mental health. These findings were published in Gerontology and Geriatric Medicine on October 25, and the research group was led by Associate Professor Kazuhiro P. Izawa (Graduate School of Health Sciences, Kobe University) and Professor Koichiro Oka (Faculty of Sport Sciences, Waseda University)
A combinatorial gene therapy approach- one designed to inhibit inflammation and one targeting protection against cartilage degeneration-was shown to preserve articulate cartilage, better than each approach alone in animal models of both moderate and severe post-traumatic osteoarthritis
A new pharmacological agent demonstrates promising results for the prevention of a wide range of heart rhythm disorders, including both cardiac and brain injury-induced arrhythmias. Furthermore, the compound (SS-68) demonstrates significant activity in reduced blood flow to the heart caused by obstructed arteries
Children and teens who suffer from a sports-related concussion should reduce, but not eliminate, physical and mental activity in the days after their injury, an American Academy of Pediatrics reports says
Use of sodium acetate cotransporter 2 (SGLT2) inhibitors to treat type 2 diabetes is associated with an increased risk of lower limb amputation and diabetic ketoacidosis (a serious diabetes complication) compared with another group of drugs called glucagon-like peptide 1 (GLP1) receptor agonists, find a study in The BMJ today