All news from Anaesthesiology

A Key Protein Holds Clues for Better Drug Design

Scientists have examined deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases. A protein called A2A adenosine receptor (A2aAR), is a member of the G-protein-coupled receptor (GPCR) family, which are the targets of roughly 40 percent of all approved pharmaceuticals.

The new, more detailed image of A2aAR's signaling mechanism reveals key parts of its inner workings, including an amino acid that acts like a "toggle switch" to control signaling across the cell membrane. This study was published in the journal Cell.

IBD: Steroid Use may Increase Thromboembolism Risk

According to a study published in the Journal of Crohn's and Colitis, steroid therapy is associated with an increased risk of venous thromboembolic events in patients with inflammatory bowel disease (IBD), but biological therapy is not . The risk of venous thromboembolism (VTE) is 1.5- to 3-fold higher in IBD patients, compared with non-IBD controls, with most events occurring during acute flare-ups of the disease.

Brachytherapy is in Decline, and Money may be Why

The evidence is clear: Cervical cancer is best treated with brachytherapy, a form of radiation therapy. Yet the use of this potentially lifesaving treatment has been declining, and a new study published in International Journal of Radiation Oncology may explain why.  The study determined that eventhough, Medicare costs hospitals more than twice as much to provide brachytherapy as it does to provide external-beam radiation, the reimbursement doesn't reflect that.

A Rejected Antibiotic Candidate worth a Second Look

The drug, called pentyl pantothenamide , is able to stop the growth of  E.coli  but not completely kill the bacterium, so it was never taken into clinical use.The study findings were published in the journal  Biochemistry , open up the possibility of designing new drugs that use the same means to attack  E. coli,  but in a more effective way.

New Skin Patch may Help Reduce Body Fat

A new approach, published in the journal Small Methods, to reducing bulging tummy fats has shown promise in laboratory trials. The discovery could help to address the worldwide obesity problem without resorting to surgical operations or oral medication which could require large dosages and could have serious side effects.

A Cluster of Mutations in Neurofibromatosis

Ludwine Messiaen led the research at the University of Alabama at Birmingham, shows that missense mutations in a cluster of just five codons in the NF1 gene are an important risk factor for severe symptoms of the genetic disease neurofibromatosis type 1.The study was published in the American Journal of Human Genetics . It shows a potential need for increased disease surveillance of patients with missense mutations in that cluster.