Some severe forms of leukemia develop because proteins on the epigenetic level lose their regulative function. Now, in a broad international collaboration, UK researchers have identified molecules that can effectively inhibit the dysregulated proteins. In the journal Angewandte Chemie, researchers report the discovery, design, and testing of potential drugs on the cellular level.
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In a study tracking the severe crisis pain of sickle cell disease and its management in 73 adults over a period of a year, Johns Hopkins researchers found that even among those on high doses of daily at-home opioids, a persistent subset was more likely to seek emergency hospital care for crisis pain and was less likely to have the pain controlled by intensive treatment.
A new specialist programme at South London and Maudsley NHS Foundation Trust (SLaM) has been shown to significantly reduce the rate of hospital readmissions for people with bipolar disorder, in an early-stage audit funded by the NIHR Maudsley Biomedical Research Centre.
Participation in the Supplemental Nutrition Assistance Program (SNAP) may reduce the number of low-income older adults with diabetes forgoing medications because of cost, according to a study published online Nov. 19 in JAMA Internal Medicine.
Severely obese patients who undergo bariatric surgery have a significantly reduced risk of developing coronary heart disease (CHD), according to a new study. The findings were presented November 14 at ObesityWeek 2018, hosted by the American Society for Metabolic and Bariatric Surgery (ASMBS) and The Obesity Society (TOS) in Nashville, Tennessee.
A new paper published by McGill University researchers in JAMA Internal Medicine suggests that some clinical trials may promote the use of ineffective and costly treatments. That's the opposite of what clinical trials are aimed at, namely preventing ineffective and costly treatments from being taken up by physicians and patients.
Fluorescent imaging with indocyanine green (ICG) can effectively guide lymphadenectomy in patients being operated on for gastric cancer, according to Korean researchers. Dr. Woo Jin Hyung of Yonsei University College of Medicine, Seoul, and colleagues enrolled 40 patients who underwent endoscopic peritumoral injection of ICG to the submucosal layer one day before robotic gastrectomy.
Children treated for obesity in primary or outpatient care have a relatively good chance of fending off weight problems over the next few years as well, a study published in Acta Paediatrica shows.
While more research is needed, scientists say the brightest prospects for the medicinal benefits of cannabis so far may lie in more complex combinations of its compounds. CBD, the non-psychoactive medicinal ingredient found in the marijuana plant, has been credited with relieving pain and inflammation, reducing epileptic seizures, quelling anxiety and insomnia, combatting some forms of cancer and even tempering acne.
Fast and easy blood pressure monitoring could soon be at your fingertips—literally—thanks to new University of British Columbia research that showed BP can be assessed by a fingertip oximeter, a tool not generally used for that purpose
In the largest study of genetic factors linked to alcohol dependence, an international team of researchers identified a gene known to affect risk, and they determined that many other genes also contribute to risk for alcohol dependence to a lesser degree.
When it comes to making health decisions for an older adult, what health surrogates don't know can be harmful, according to new research. While 75% of surrogates feel extremely confident in their knowledge of a loved one's preferences, only 21% of them actually know what the older patient would want in the event of a serious illness, the researchers said