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Study Finds, Drug Safety in Hospitalized Pediatric Patients

The results of the study, recently published in BMC Pharmacology and Toxicology, identified 19 ADRs out of a total of 1,083 hospital admissions.The most frequently prescribed drug classes were antibiotics and anti-inflammatory drugs. The approximate incidence of ADRs in children was17per 1,000 children.Most of the ADRs involved antibiotics and 21% of the ADR’s were categorized as “preventable”. The severest ADRs observed during the study were haemolysis and toxic epidermal necrolysis.

Assessment of Patient and Physician Ratings of Surgical Scars.

A new study published in the JAMA Facial Plastic Surgery has showed that disagreement between physician- and patient-reported scar assessment is not uncommon. Neither patients nor clinicians consistently detect differences in scars using current scar assessment instruments. Patients and physicians differ in their evaluation of surgical scars. Scar instruments that better integrate both patient and clinician scar ratings may aid in determining the most salient features of cutaneous scars.

Lung recritment assessed by Electrical Impedance Tomography

The aim of the present study was to compare, in intubated patients with acute hypoxemic respiratory failure (AHRF) and acute respiratory distress syndrome (ARDS), lung recruitment measured by P-V curve analysis, with dynamic changes in poorly ventilated units of the dorsal lung (dependent silent spaces [DSSs]) assessed by electrical impedance tomography (EIT). Researchers hypothesized that DSSs might represent a dynamic bedside measure of recruitment.

Prognostication of Breast Cancer Risks in Southern Sri Lanka

Although, there are many developments in the field of management, breast cancer is still the commonest cause of cancer related deaths in women in Sri Lanka. This emphasizes the need for validation of treatment protocols that are used in Sri Lanka for managing breast cancers.

There are no published papers on treatment and survival of breast cancer patients in Sri Lanka. Hence this study was designed to determine the validity of St Gallen risk categories based on the survival outcomes of breast cancer patients in Southern Sri Lanka.

TEG-based Resuscitation versus Empirical 1:1 Transfusion

Thomboelastography (TEG) is a whole blood measure of coagulation which was originally described in the 1950s. However, it has only been in the last few decades that assays have become accessible and viable as a point-of-care test. Following the observation that hemorrhagic shock is associated with an intrinsic coagulopathy, TEG has been used as a method of diagnosing specific coagulation defects in order to direct individualized blood products resuscitation. An alternative transfusion strategy is the administration of fixed ratio products, a paradigm borne out of the military experience.