Cardiovascular diseases (CVDs) are proven to be the leading cause of deaths throughout the world. If statistics are reviewed, almost four out of five deaths are due to myocardial infarction or stroke.
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In autoantibody-mediated autoimmune diseases, autoantibody profiling allows stratifying patients and link autoantibodies with disease severity and outcome. However, in immune-mediated thrombotic thrombocytopenic purpura patients, stratification according to antibody profiles and their clinical relevance has not been fully explored.
Natural killer (NK) cells are attractive candidates for allogeneic cell-based immunotherapy due to their potent antitumor effector function and good safety profile. NK cells express killer immunoglobulin-like receptors (KIRs) and the NKG2A receptor important for NK cells education as well as providing inhibitory signals upon encountering HLA-expressing target cells. Multiple myelomas (MM) is an example of a tumor expressing relatively high levels of HLA molecules.
Cardiovascular disease, including coronary artery disease (CAD) and ischemic stroke, is the leading cause of death worldwide. This Mendelian randomization study uses genetic variants as instruments to investigate whether there is a causal effect of genetically determined platelet count on CAD and ischemic stroke risk.
Admissions of infants in England have increased substantially but there is little evidence whether this is across the first year or predominately in neonates, and for all or for specific causes. The aim was to characterize this increase, especially those admissions that may be avoidable in the context of postnatal care provision.
Compared to younger individuals, the prevalence of end-stage renal disease (ESRD) in elders is notably higher. While renal replacement therapy, usually with hemodialysis, is accepted therapy in younger patients with ESRD, decisions regarding the treatment of advanced kidney disease in the elderly population are more complex, secondary to the physiologic changes of aging, concurrent geriatric syndromes, and varying goals of care.
The researchers hypothesized that the universal adoption of closed low blood pressure therapy (NPWT) in emergency general surgery would result in low superficial surgical infection (SSI) rates.
The effect of vitamin D supplementation on postural muscles of the trunk is of particular interest because low 25-hydroxyvitamin D [25 (OH) D] levels are associated with decreased postural balance and increased risk of falls.
Understanding the role of vitamin D supplementation plays in trunk muscle function of older adults is necessary, as this is a potentially modifiable factor to improve postural muscle function and decrease the risk of falling of older adults.
Presently, there are no therapeutic options for unresectable hepatocellular carcinoma (u-HCC) patients who are intolerant to sorafenib or regorafenib failure. There have been no reports with detailed clinical findings of lenvatinib (LEN), a newly developed first-line tyrosine kinase inhibitor (TKI), obtained in real-world practice. We aimed to elucidate the therapeutic efficacy of LEN.
Hypertension remains poorly controlled on the population level. National rates of control, even when defined leniently by BP <140/90 mmHg, are only ~ 50%. As growing healthcare costs coincide with blood pressure (BP) targets, innovative management programs are needed to maximize the efficiency of care delivery and optimize control.
A new study conducted by a researcher from Columbia University's Mailman School of Public Health suggests that all infectious diseases are driven by seasonal elements.
Researchers applied a machine learning technique that could potentially translate patterns of activity in fear-processing brain regions into scores on questionnaires used to assess a patient's fear of pain. This neuroscientific approach may help reconcile self-reported emotions and their neural underpinnings.