All news from Anatomy

PADN-5: Ablation Reduces Pulmonary Hypertension in HF

Patients with combined pre and postcapillary  pulmonary hypertension  (CpcPH) secondary to left-sided  heart failure  (HF) who underwent a pulmonary artery denervation (PADN) procedure had significant improvements in hemodynamic and clinical outcomes at 6 months, compared with patients who underwent a sham procedure, in the PADN-5 trial.

Enzyme's Unfrozen Adventure: In Crystallo Protein Thermodynamics

Researchers a have reported the first in crystallo thermodynamic analysis of copper amine oxidase catalysis using a non-cryocooled technique. The method, which analyzes protein crystals coated with a water-soluble polymer, rather than cryogenically cooled crystals, can be temperature-controlled, allowing for conformational changes to be monitored over a range of temperatures. Additionally, the conditions show parallels with the cytosol, meaning that the approach could provide a useful model for protein behavior in cells.