The largest observational cohort study to assess the outcomes of nonmedical (mandated) switching of inflammatory arthritis patients from etanercept (ETA) to the biosimilar SB4 in routine clinical care supports SB4 efficacy and safety but does not fully resolve concerns about switching between originator biologics and biosimilars.
How does a normal cell turn into deadly cancer? Seeking an answer to this question, and working alongside other international working groups, researchers from Charité Universitätsmedizin Berlin examined the tumor genomes of nearly 300 prostate cancer patients.
Already affecting more than five million Americans older than 65, Alzheimer's disease is on the rise and expected to impact more than 13 million people by 2050. Over the last three decades, researchers have relied on neuroimaging brain scans such as magnetic resonance imaging (MRI) or positron emission tomography (PET) to study Alzheimer's disease and other neurodegenerative diseases.
New research led by the Hip Implant Prosthesis Study (HIPS) team at the University of Bristol Medical School has shown that small-head (less than 36 mm in diameter) cemented metal-on-plastic hip replacements are the most cost-effective in men and women older than 65 years.
Saint Louis University researchers are studying how fetal exposure to inflammation can alter immune responses after birth.
In head-to-head comparisons, two of five dry eye screens showed a statistically significant ability to detect signs of the disorder, but all demonstrated relatively modest diagnostic accuracy, researchers say.
Pregnant women routinely swear off alcohol and tobacco to boost their chances of having a healthy baby. What about common food allergens like nuts and milk?
A new study has examined how countries around the world compare in providing reimbursement for dialysis care received by patients with kidney failure.
A new review of data from 250,726 trial participants has found that 1 in 20 people who took placebos in trials dropped out because of serious adverse events. Almost half of the participants reported less severe adverse events. The adverse events ranged from abdominal pain and anorexia to burning, chest pain, fatigue, and even death.
Medical researchers at Melbourne's Murdoch Children's Research Institute have discovered how a baby's sex is determined and it's not just about the XY chromosomes , but involves a 'regulator' that increases or decreases the gene activity which decides if we are male or female.
In general, women who have had children have a lower risk of breast cancer compared to women who have never given birth. However, new research has found that moms don't experience this breast cancer protection until many years later and may face an elevated risk for more than 20 years after their last pregnancy.
With a new crew arriving at the International Space Station, astronauts will be relieved to know that they will not have to worry about a major aspect of their immune system being compromised. While scientists know about the astronauts' skeletal and muscular health during spaceflight and when they return to Earth, much less is known about how spaceflight affects immunity. It has been generally thought, until now, that spaceflight has a detrimental impact on all aspects of the immune system.