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Metabolites from Octocoral-Associated Microbes

Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved.

Combating Drug-resistant Microbes: Phage Therapy Draws Renewed Interest

The married professors were spending their Thanksgiving holiday in Egypt when the husband, Thomas L. Patterson, Ph.D., got very sick very quickly, experiencing fever, nausea and a racing heartbeat. By the time Patterson was accurately diagnosed with a highly multi-drug resistant bacterial infection, he was near death. His wife, Steffanie Strathdee, Ph.D., promised to leave no stone unturned.

Haemophagocytic Syndrome Hospitalisations In Children

The haemophagocytic syndrome (HS) is a rare condition that presents with uncontrolled inflammation leading to multiorgan failure and is associated with significant morbidity and mortality. Current national estimates of children hospitalized due to HS are unknown. Characterizing and understanding the burden of HS-related hospitalizations at a national level is the initial step in optimizing the overall care.

Improving Prescribing for Older Patients

Polypharmacy and inappropriate prescribing are associated with negative health outcomes in the elderly. Several prescribing tools have been developed to assess medication appropriateness. Explicit (criteria-based) tools often do not consider patients’ preferences and comorbidities and have little room for individualized clinical judgment.