All news from Nephrology

Mycobacterium Chimaera Infections, An Ongoing Global Outbreak

An ongoing global outbreak of Mycobacterium chimaera infections is associated with contamination of a widely used surgical device, the 3T heater-cooler unit, researchers report. The outbreak began in Switzerland in 2011, and since then the Swiss Chimaera Taskforce estimates an annual incidence of 156-282 cases for the Ten major valve replacement markets, with 51-80 cases in the U.S. alone.

In Toxoplasma gondii, Protein Targets of Thiazolidinone Derivatives Elaborated

Thiazolidinone derivatives show inhibitory activity (IC50) against the Toxoplasma gondii parasite, as well as high selectivity with high therapeutic index . To disclose the target proteins of the thiazolidinone core in this parasite, researchers explored in silico the active sites of different T. gondii proteins.

Researchers estimated thiazolidinone molecules with an inhibitory effect on invasion and replication of the parasite inside host cells. This enabled us to describe some of the most suitable structural characteristics to design a compound derived from the thiazolidinone core