Chronic kidney disease (CKD) is a serious health problem due to high mortality and morbidity, negative impact on the patients' quality of life (QOL), high diagnostic and therapeutic cost, and the burden on society.
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The first oral-only treatment for human African trypanosomiasis (HAT), commonly known as sleeping sickness, has received a green light from the Committee for Human Medicinal Products (CHMP) of the European Medicines Agency (EMA).
Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide are secondary metabolites formed by Fusarium graminearu. Evidence for formation of DON-glutathione adducts exists in plants, and also in human liver (HepG2) cells mass spectrometric evidence for GSH-adduct formation was reported
Patients undergoing cardiac surgery are at high risk for postoperative delirium, which is associated with longer hospital and intensive care lengths of stays increased morbidity and mortality. Because sleep disturbances are common in delirium, melatonin has been an area of interest in the treatment of delirium.
An ongoing global outbreak of Mycobacterium chimaera infections is associated with contamination of a widely used surgical device, the 3T heater-cooler unit, researchers report. The outbreak began in Switzerland in 2011, and since then the Swiss Chimaera Taskforce estimates an annual incidence of 156-282 cases for the Ten major valve replacement markets, with 51-80 cases in the U.S. alone.
There were as many as 900,000 "preventable" unplanned Caesarean section (C-section) deliveries out of 7 million in private hospitals in India in one year, driven mainly by "financial incentives," says a study by Indian Institute of Management-Ahmedabad.
Early screening and diagnosis are important for minimizing gestational adverse outcomes. Routine screening of gestational diabetes mellitus (GDM) at 24-28 weeks with 75 g oral glucose challenge test (OGCT) leaves limited time for intervention and prevention. This study aims to analyze maternal serum peptides in the early second-trimester for prediction of gestational diabetes mellitus (GDM)
Allergic rhinitis (AR) is an IgE-mediated type 1 hypersensitivity reaction of nasal mucosa in response to an antigenic substance (allergen). It is a common disorder among children. In Nigeria, the prevalence of AR among children with asthma was 39.2%.
Thiazolidinone derivatives show inhibitory activity (IC50) against the Toxoplasma gondii parasite, as well as high selectivity with high therapeutic index . To disclose the target proteins of the thiazolidinone core in this parasite, researchers explored in silico the active sites of different T. gondii proteins.
Researchers estimated thiazolidinone molecules with an inhibitory effect on invasion and replication of the parasite inside host cells. This enabled us to describe some of the most suitable structural characteristics to design a compound derived from the thiazolidinone core
The adipose tissue homeostasis is profoundly affected by circadian rhythms of corticosteroid secretion and chronic loss of hormonal oscillations is associated with obesity. How adipose tissue differentially responds to pulsatile vs continuous presence of glucocorticoids is poorly defined.
Mild traumatic brain injury is a leading cause of death and disability worldwide with 42 million cases reported annually, increasing the need to understand the underlying pathophysiology because this could help guide the development of targeted therapy. White matter, particularly the corpus callosum, is susceptible to injury.