Despite recent technological advances in radiotherapy, challenges relating to tumor targeting, dose limitations, and tumor relapse and escape remain. Multiple strategies for targeting cancer cells, cancer stem cells (CSCs), tumor stroma, and tumor endothelial cells (ECs), as well as improving anti-tumor immune responses to increase tumor radiosensitivity, are being developed
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For a child, recovering from a broken bone is typically a short-lived, albeit painful, convalescence. But for older adults, it can be a protracted and potentially life-threatening process. Finding ways to speed bone repair is a public health priority that could save both lives and health care expense.
The investigational drug luspatercept (under development by Acceleron and Celgene) has been shown to reduce the need for blood transfusions in two separate patient populations.
An international phase-2 trial of a CAR-T cell therapy -to be published online Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego) -found that 52% of patients responded favorably to the therapy; 40% had a complete response and 12% had a partial response.
A follow-up analysis of patients enrolled in Phase I / II multi-center trial for diffuse large B-cell lymphoma (DLBCL) reported 51% of patients receiving an anti-CD19 chimeric antigen receptor (CAR T) called axi-cel were still alive two years post-treatment.
Admission to a hospital ward with below average numbers of fully trained (registered) nurses to care for patients is linked to a 3% rise in the risk of death for each day the shortfall persists, suggests UK research published online in the journal BMJ Quality & Safety.
Different factors were associated with falling in men versus women in a study of 3,112 community-dwelling adults aged 60 years and older. The findings are published in the Journal of the American Geriatrics Society.
New research led by the Hip Implant Prosthesis Study (HIPS) team at the University of Bristol Medical School has shown that small-head (less than 36 mm in diameter) cemented metal-on-plastic hip replacements are the most cost-effective in men and women older than 65 years.
Two genes normally work together to suppress the development of colon cancer. Their combined loss favors tumorigenesis and stimulates the formation of metastases. Colon cancers can be successfully treated by surgical resection if the illness is already diagnosed after the appearance of the primary tumor.