Glutamate is the major excitatory neurotransmitter in the brain, and the postsynaptic expression level of glutamate receptors is a critical factor in determining the efficiency of information transmission and the activity of the neuronal network. Therefore, glutamate receptor trafficking is critical to the physiological function of human brain circuitry
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Two molecularly distinct sub-phenotypes of acute kidney injury (AKI) are associated with different clinical outcomes and response to vasopressin therapy, according to a study published in the American Journal of Respiratory and Critical Care Medicine
Men presenting with aggressive prostate cancer—Gleason Score of 9 or 10—comprise most of those who will die from prostate cancer worldwide, and despite surgical removal of the prostate (radical prostatectomy), their cancer will recur more than 80 percent of the time
Researchers and clinicians through a multicenter collaboration have identified a novel multisystem disorder caused by bi-allelic variants in the CCDC47 gene. Their findings are reported in the American Journal of Human Genetics
A collaboration of scientists from the University of Massachusetts Medical School, Beth Israel Deaconess Medical Center and Western Sydney University, has shown that an innovative new type of therapy using small interfering RNAs (siRNA) can temper the symptoms of preeclampsia in an animal model
A South American tribe living in near-total isolation with no Western dietary influences showed no increase in average blood pressure from age one to age 60, according to a study led by Johns Hopkins Bloomberg School of Public Health. In comparison, a nearby tribe whose diet includes some processed foods and salt did show higher blood pressure into late middle age.
Tick-borne diseases are once again on the rise in the United States, and the reasons are not clear, the Centers for Disease Control and Prevention (CDC) said in a news release.
More and more bacteria are resistant to available antibiotics. A team of chemists now presents a new approach: they have identified important enzymes in the metabolism of staphylococci. Blocking these enzymes in a targeted manner would allow the pathogens to be starved.
Researchers used ultrabright x-rays to generate 3D nanoscale maps of a single bacteria's chemical composition with unparalleled spatial resolution. Scientists at the National Synchrotron Light Source II (NSLS-II) have used ultrabright x-rays to image single bacteria with higher spatial resolution than ever before. Their work, published in Scientific Reports, demonstrates an x-ray imaging technique, called x-ray fluorescence microscopy (XRF), as an effective approach to produce 3-D images of small biological samples.
A new study led by researchers at Massachusetts Eye and Ear found that good performance on a piloting task was associated with lower vestibular thresholds, which represent stronger ability to sense and perceive information about motion, balance and spatial orientation. Published online today in the Journal of Neurophysiology, the findings suggest that astronauts or pilots with higher vestibular thresholds are more likely to become disoriented during flight, especially in situations when gravity is less than that on Earth-such as on the Moon.
These days, mammals can use their forelimbs to swim, jump, fly, climb, dig, and just about everything in between, but the question of how all that diversity evolved has remained a vexing one for scientists. To help answer it, Harvard researchers are turning to one of the most unusual mammals around – echidnas. These sprawling, egg-laying mammals have many anatomical features in common with earlier mammal ancestors, and so can help bridge the gap between extinct and other modern-day mammals.