All news from Anatomy

Role of Proteins to Break up Energy Structures in Oxygen Starved Heart Cells

Researchers found that the filamin A-Drp1 complex mediates mitochondrial fission in a mouse model of hypoxic heart cells. Results show that hypoxic stress brought about the interaction of filamin A with Drp1 and increased Drp1 activity in heart cells. This process led to mitochondrial fragmentation and cell senescence. Further investigation demonstrated that the drug cilnidipine suppressed Drp1-filamin A complex formation and preserved heart cell function.

Rise in Mortality Risks with Social Isolation, Study

A large study links social isolation with a higher risk of death from all causes combined and heart disease for all races studied, and with increased cancer mortality in white men and women. The study, appearing in the  American Journal of Epidemiology, says addressing social isolation holds promise if studies show interventions are effective, as they could be relatively simple and could influence other risk factors, as social isolation is also associated with hypertension, inflammation, physical inactivity, smoking, and other health risks.

Bacterial Evolution: Dodging Antibiotic Resistance by Curbing It

Lowering mutation rates in harmful bacteria might be an as yet untried way to hinder the emergence of antimicrobial pathogens. One target for drug development might be a protein factor, DNA translocase Mfd, which enables bacteria to evolve rapidly by promoting mutations in many different bacterial species.

This action speeds antibiotic resistance, including multi-drug resistance. Working on drugs to block Mfd and similar factors could be a revolutionary strategy to address the worldwide crisis of treatment-resistant infectious diseases.