Mice with heart failure that were treated with AAV8-based gene therapy to deliver the protein urocortin 3 (UCn3) had increased blood levels of UCN3 over a 5-week period and improved heart function. The mice received a single injection of AAV8.UCn3 after cryoinjury to induce left ventricular heart failure and showed significant improvements in both systolic and diastolic heart function, as reported in an article published in Human Gene Therapy
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University at Buffalo has found that college students preferred food deprivation over smartphone deprivation, according to results from a paper in Addictive Behaviors. Sara O'Donnell, the lead author on the paper and clinical psychology doctoral student in the Department of Pediatrics in the Jacobs School of Medicine and Biomedical Sciences at UB, said the results suggest that smartphones can be more reinforcing than food for college students
After a prophylactic double mastectomy in 2015, Tina Harrison discovered that she had, indeed, had breast cancer-it just had not been detected. Harrison, of Pinckney, Mich., Accurately predicted the cancer-it ran in her family but she did not anticipate her ongoing pain and loss of shoulder function after reconstructive surgery
Infant gut microbes altered by their mother's obesity can cause inflammation and other major changes within the baby, increasing the risk of obesity and non-alcoholic fatty liver disease later in life, according to researchers at the University of Colorado Anschutz Medical Campus
Move more, sit less and get kids active as young as age 3, say new federal guidelines that stress that any amount and any type of exercise helps health. The advice is the first update since the government's physical activity guidelines came out a decade ago. Since then, the list of benefits of exercise has grown, and there's more evidence to back things that were of unknown value before, such as short, high-intense workouts and taking the stairs instead of an elevator
Chronic inflammatory rheumatic diseases such as rheumatoid arthritis (RA) and spondyloarthritis (SpA) are chronic, disabling diseases with a poor outcome for loco-motoric function if left untreated. RA and SpA each affect about 1 percent of the population. The reason that certain joints are more affected than others has been a longstanding question, now resolved by Isabelle Cambré and Prof. Dirk Elewaut from the VIB-UGent Center for Inflammation Research. The results appear in Nature Communications
An experimental drug may be effective against a deadly form of pancreatic cancer when used in combination with other immune-boosting therapies, according to a study cover online Nov. 12 in Cancer Cell
Many parents probably think nothing of sucking on their baby's pacifier to clean it after it falls to the ground. Turns out, doing so may benefit their child's health. A Henry Ford Health System study found that babies whose parents have sucked on their pacifier to clean it at a lower level of the antibody that is linked to the development of allergies and asthma
Researchers from Chalmers University of Technology, Sweden, have discovered how our bones grow at an atomic level, showing how an unstructured mass orders itself into a perfectly arranged bone structure. The discovery offers new insights, which could yield improved new implants, as well as increasing our knowledge of bone diseases such as osteoporosis
By combining two imaging modalities-adaptive optics and angiography-investigators at the National Eye Institute (NEI) can see live neurons, epithelial cells, and blood vessels deep in the eye's light-sensing retina.
Over the past three decades, there has been a steady increase in the average age of parents. Advances in fertility science mean that people, literally, put their eggs or sperm on the ice and delay the start of parenthood. Many large companies, such as Apple, Facebook, and Google, now offer egg freezing to employees as part of their healthcare package. Putting off having a baby has never been easier or more socially acceptable. But is it a good thing?
To Evaluate the diagnostic performance of 18 F-choline PET-CT in staging prostate cancer (PC) and the use of esta Whether imaging modality changes the therapeutic decision in Patients with previously staged by conventional imaging. The secondary aim was to determine the prognostic factors associated with positive choline PET-CT findings in both detections of disseminated disease and changes in the therapeutic indication