Tokyo Medical and Dental University (TMDU)-led study shows that, in some patients, the somatic reversion of SLAM-associated protein expression in T cells leads to a mild form of X-linked lymphoproliferative syndrome type 1.
Although it has long been recognized that mutations of gene NPM1 play an important role in acute myeloid leukemia, no one has determined how the normal and the mutated forms of the protein NPM1 function.
Individual and work-related factors may be helpful in promoting positive engagement with work among hospital physicians, according to a study in the December issue of Medical Care. The study provides insights into the emerging evidence on the characteristics and outcomes affecting physician engagement an area of growing focus in healthcare improvement efforts.
A team of Salk Institute researchers led by President Rusty Gage has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and Cognitive Impairment to investigate mechanisms underlying Alzheimer's disease and aging-related cognitive decline and uncover new therapies.
Analyzing data from more than 2,400 obese patients who underwent bariatric weight-loss surgery, researchers identified at least four different patient subgroups that diverge significantly in eating behaviors and rate of diabetes, as well as weight loss in three years after surgery.
The continuation of drugs that are not intended to be taken indefinitely is a substantial and common problem that could contribute to over-medication, particularly in the elderly. The specific number of drugs taken is not itself indicative of polypharmacy as all of the drugs may be clinically necessary and appropriate for the patient; however, as the number of prescribed drugs increases, so do the chances of Polypharmacy.
For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors (ICIs).
The Antimicrobial Stewardship Research Workshop, hosted by the Society for Healthcare Epidemiology of America (SHEA), will prepare healthcare professionals to design, deploy, and evaluate antibiotic stewardship interventions to combat the emergence of deadly drug-resistant bacteria.