All news from Palliative Medicine

BH3 Mimetics Induce Apoptosis Independent Of DRP-1 In Melanoma

Think of the protein BH3 like a finger that turns off to cancer cell survival switch. The problem is that most cancer cells have found ways to remove this "finger commonly, by breaking the action of a gene called p53 that puts the BH3 finger in motion.

Now think of Bcl-2 as the switch itself. When cancer breaks p53, the BH3 finger never moves, and the Bcl-2 survival switch remains on. Despite thousands of published studies, researchers have not had much luck directly protecting the action of p53. But, BH3 is another story.

The study was published in the journal Cell Death and Disease.

Defensive ICD Programming Is Safe & Reduces Inappropriate Therapy

Sudden cardiac death is a common cause of death in patients with congenital or acquired heart disease. An implanted cardiac defibrillator (ICD) can effectively put a stop to any underlying cardiac arrhythmia. In a long-term observational study involving 1,500 patients.

Researchers have shown that the progress selected for the implanted defibrillators (ICDs) plays a major role. It was found that the most "defensive" possible procedure is safe and, at the same time, significantly reduces inappropriate therapy.

The study was published in Circulation.

Druk Nyamrup Tshogpa: Change in Bhutan, Handle with Care

Bhutanese voters have given a decisive mandate to the Druk Nyamrup Tshogpa (DNT) in the just-concluded third round of the country's third general elections. A new party, established only in 2013, the DNT secured 54% of the votes and won 30 of the 47 seats in the National Assembly. With 17 seats, runner-up Druk Phuensum Tshogp heartening that they are expressing their support for change via the ballot box.