All news from Anaesthesiology

Promising Allergy Vaccine for Hay Fever Developed

Using sugar molecules researchers from the University of Copenhagen have developed a new vaccine for hay fever that may reduce treatment times and increase the effectiveness of treatments. The vaccine, which is still at the earliest research stage, has been tested on mice. The method can potentially also be used to develop different forms of vaccines, for example, vaccines for autoimmune disorders.

Heart-Muscle Cells Grow Up

Scientists have been trying to replace damaged heart tissue using lab-made heart-muscle cells, either injected or in patch form. But the resulting muscle doesn't work very well because the cells are stuck in an immature stage. Using a novel CRISPR/Cas9 technique, a new study finds a master gene, that's required for the cells to become fully fledged, contractile adult cells.

Scientists around the world have been trying to replace damaged heart tissue using lab-made heart-muscle cells (cardiomyocytes), either injecting them into the heart or applying patches laced with the cells. But results to date have been underwhelming. The study was published in Nature Communications.

Smarter Strategies To Treat Atrial Fibrillation

Atrial fibrillation is the most common type of irregular heartbeat, or cardiac arrhythmia, affecting 2-3 % of the European population and as many as one in 10 people over the age of 80. Its prevalence is expected to double or triple in the next few decades as the population ages, significantly increasing the burden on healthcare systems.

The EU-funded CATCH ME project is addressing that challenge by providing innovative digital tools to enhance clinical practice, and by conducting groundbreaking research into the mechanisms and effects of atrial fibrillation in order to improve treatment.

New Test Tells Time of Internal Clock

Timing is everything, and it also has a huge impact on your health. Now there’s a blood test to better understand your internal time clock and optimize it for better well-being. The TimeSignature test was developed by researchers at Northwestern Medicine scientists.

It requires two blood draws. It offers insights through gene expression markers into the time in your body compared to time in the external world. For instance, it may be 8 a.m., but your body may be operating as if it’s 6 a.m. Previously, determining a person’s internal clock could only be done by drawing blood multiple times over a specific span.

The test, which measures 40 different gene expression markers in the blood, can be performed any time of day, regardless of the patient’s circadian pattern or level of restfulness. The study was published in PNAS earlier this month.

Entrectinib Against ROS1+ Non-Small Cell Lung Cancer

Results of phase 1 and phase 2 clinical trials of the drug entrectinib in ROS1-positive non-small cell lung cancer (NSCLC) presented on the press program of the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer show a response rate of 77.4% for 53 patients evaluable for response, with median duration of response of 24.6 months. The trial included patients with untreated and treated brain metastases at baseline.

Tuberculosis Research: NIAID Releases Strategic Plan

Tuberculosis (TB) is the leading infectious cause of death worldwide, killing roughly 1.6 million people in 2017. In the past 200 years, TB claimed the lives of more than one billion people—more deaths than from malaria, influenza, smallpox, HIV/AIDS, cholera, and plague combined.