All news from Maternity & Child Health

The Real India Growth Story; Nutrition Policy

India has world's third-highest number of billionaires. But at the same time, hidden hunger – micro-nutrient deficiency – continues to be a major public health issue. Today, India has an astounding 190 million undernourished people , the highest in the world. About 47.5 million Indian children under-5 years are stunted -again, the most in the world.

Bacterial Vaginosis: Better Communication between Patients and HCPs Highlighted

According to an online survey, although healthcare providers (HCPs) report sharing crucial information on bacterial vaginosis (BV) with patients, the associated risks of the condition remain a mystery to many women, indicating a significant disconnect. With BV known to be the most prevalent gynecologic infection in the U.S., affecting 21 million women each year, it's clear that further education is needed to bridge this gap in communication and help women to obtain diagnosis and treatment initiation sooner.

Drug-Resistant Infections Cured Without Antibiotics

Biochemists, microbiologists, drug discovery experts, and infectious disease doctors have teamed up in a new study that shows antibiotics are not always necessary to cure sepsis in mice. Instead of killing causative bacteria with antibiotics, researchers treated infected mice with molecules that block toxin formation in bacteria. Every treated mouse survived. The breakthrough study, published in Scientific Reports, suggests infections in humans might be cured the same way.

Development of Effective Antibiotics by Understanding Metal-Free Enzymes Used by Bacteria

Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions. This process may allow infectious bacteria to replicate even when the host's immune system sequesters iron and manganese ions in an attempt to slow pathogen replication.

A new study, which appears in the journal Proceedings of the National Academy of Science, describes a novel subclass of metal-free ribonucleotide reductase enzymes used by these bacteria, an understanding of which could drive the development of new, more effective antibiotics.

DNA Vaccine Strategy Against Multiple H3N2 Viruses, Findings

Researchers developed a novel DNA influenza vaccine based on four micro-consensus antigenic regions selected to represent the diversity of seasonal H3N2 viruses across decades. The DNA vaccine protected mice against a lethal challenge with more than one influenza-A H3N2 virus.

It also protected them from severe H3N2-related illness despite the lack of an exact sequence match between the vaccine immunogen and H3 immunogen. The findings are reported in a new Special Issue on DNA Vaccines in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Clinical Trials of Functional Engineered Oesophagus In-Process

The world's first functional oesophagus engineered from stem cells has been grown and successfully transplanted into mice, as part of a pioneering new study led by UCL. It was hoped this research, carried out by UCL Great Ormond Street Institute of Child Health (ICH), in collaboration with Great Ormond Street Hospital (GOSH) and the Francis Crick Institute, could pave the way for clinical trials of lab-grown food pipes for children with congenital and acquired gut conditions.