All news from Physiology

New Insights Into Gene Underlying Circadian Rhythms

Innovative cardioprotective strategies are of imminent demand. Nonfatal myocardial ischemia (MI) poses a significant risk to patients undergoing major non-cardiac surgery and these non-cardiac surgeries account for around 8 million myocardial injuries per year.

Considering perioperative MI is the most common major cardiovascular complication, identifying factors that lead to cardiac disease onset and finding solutions to prevent potential cardiac damage is of critical importance.

Previous work revealed that anesthetics used in the perioperative setting alter the cellular circadian biology and furthermore, a critical role for the circadian rhythm protein Period 2 (PER2) was revealed in promoting cardioprotection through metabolic pathway mediation.

Reduced Mortality with Increased Cardiorespiratory Fitness, Experts Find

Cleveland Clinic researchers have found that better cardiorespiratory fitness leads to longer life, with no limit to the benefit of aerobic fitness. Researchers retrospectively studied 122,007 patients who underwent exercise treadmill testing at Cleveland Clinic between Jan. 1, 1991, and Dec. 31, 2014, to measure all-cause mortality relating to the benefits of exercise and fitness. The paper was published today in the Journal of the American Medical Association Network Open.

Diabetes Type 1 And Type 2 Adult Vaccination

Diabetes reduces the immune system's ability to fight certain infections. This raises the risk of dangerous diseases from vaccines to protect against-including flu, pneumonia, hepatitis B, tetanus and shingles.

People with diabetes may be at higher risk of getting certain diseases and also serious problems from diseases that could have been prevented with vaccines. Everyone should know what vaccines they need to protect themselves and discuss with their doctor if they are up to date with the vaccines.

Human Neuronal Differentiation For Functional Investigation of Schizophrenia Polygenic Risk

Researchers examined the process in which new neurons were designated for certain roles, and found that changes in gene expression over the course of neural development were significantly associated with genetic risk for schizophrenia.

They have established a new analytical method for investigating the complex genetic origins of mental illnesses using brain cells that are grown in a dish from human embryonic stem cells. The study was published in Biological Psychiatry.