The world's first functional oesophagus engineered from stem cells has been grown and successfully transplanted into mice, as part of a pioneering new study led by UCL. It was hoped this research, carried out by UCL Great Ormond Street Institute of Child Health (ICH), in collaboration with Great Ormond Street Hospital (GOSH) and the Francis Crick Institute, could pave the way for clinical trials of lab-grown food pipes for children with congenital and acquired gut conditions.
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A new study implicates the remodeling of nerves in the airways as a key contributor to heightened sensitivity and airway constriction in patients with asthma. The results provide new insight into a little-understood factor in the development of asthma, a condition that affects about 235 million people worldwide. The study is the first to demonstrate that inflammatory cells can alter nerve structure in the lungs to cause disease.
Hospitals should be cautious of group purchasing organizations, or entities that act as middlemen between health care providers and manufacturers, says Martin Makary, M.D., M.P.H., a professor of surgery at the Johns Hopkins University School of Medicine.
A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more sensitive to radiation therapy, according to a recent study led by researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.
The hidden lives of medical biomarkers are the focus of a recent study in Nature Communications by Jonathan Mosley, MD, Ph.D., assistant professor of Medicine and Biomedical Informatics, and colleagues from Vanderbilt University Medical Center and 11 other institutions.
Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies. The lymphatic system is a network of vessels and lymph nodes that spans the entire body.
Air pollution in the U.S. has decreased since about 1990, and a new study conducted at the University of North Carolina at Chapel Hill now shows that this air quality improvement has brought substantial public health benefits. The study, published in the journal Atmospheric Chemistry and Physics, found that deaths related to air pollution were nearly halved between 1990 and 2010.