All news from Pharmacology and Therapeutics
Yale has developed a way to target RNA with small-molecule drugs, creating a new method for tapping into a vast number of biological mechanisms critical to metabolism and gene expression.
"There is tremendous interest in targeting RNA with small molecules," said Yale biochemist Anna Pyle, whose lab conducted the research. Despite this potential, there has been limited progress on the development of small-molecule drugs that bind RNA, and a pervasive view that RNA is not a viable therapeutic target.
A survey undertaken by the Bone Cancer Research Trust (BCRT) has revealed a diagnosis of breast cancer patients. The survey of 394 primary bone cancer patients, survivors, and bereaved families showed that one in four patients (26%) had waited over seven months before receiving a diagnosis with 13% waiting over a year
Lower back pain happens to millions of Americans every year, and back pain is caused by a number of reasons. If your back pain keeps coming back and it's not because of your mattress it's wrong for you-it might be time to investigate if something more serious is causing the problem
Researchers have developed designer molecules that may one day be able to seek out and trap deadly nerve agents and other toxic compounds in the environment – and possibly in humans.
New research highlights a more accurate way to screen for preeclampsia in pregnant women than currently recommended methods. Published early online in Ultrasound in Obstetrics & Gynecology, the study challenges the UK's current guidelines on the management of hypertensive disorders during pregnancy.
A new study led by investigators at Brigham and Women's Hospital and Harvard THR Chan School of Public Health is the first to look at the results of the black men and to whether an optimized screening strategy with baseline prostate-specific antigen (PSA) levels predict prostate cancer in this population
According to recent research, endurance exercise training beneficially modifies gut microbiota composition. After six weeks of training, potentially inflammation causing microbes (Proteobacteria) decreased and microbes that are linked to enhanced metabolism (Akkermansia) increased.
Mistakes in "proofreading" the genetic code of retinal cells is the cause of a form of inherited blindness, retinitis pigmentosa (RP) caused by mutations in splicing factors. This new understanding of the disease process, published in Nature Communications, is leading to the development of a gene therapy for RP caused by splicing factor defects.
Cesarean-born mice show altered patterns of cell death across the brain, exhibiting a greater nerve cell death than vaginally delivered mice in at least one brain area, a finding by Georgia State University that suggests that it may have effects on human neurodevelopment that may lead to long-lasting changes in the brain and behavior.
The formation of protein complexes is a highly organized process that does not begin with the "finished" proteins. Researchers demonstrate that they form in a coordinated way when the protein subunits are synthesized.
Our findings fundamentally alter our understanding of how biologically active protein complexes form in the cell. The study was published in Nature
A research group presented a novel biosensor which can produce diverse, high-level microbial cell factories. The biosensor monitors the concentration of products and even intermediates when new strains are being developed. This strategy provides a new platform for manufacturing diverse natural products from renewable resources. The team succeeded in creating four natural products of high-level pharmaceutical importance with this strategy.
