All news from Anaesthesiology

Cells Alter tRNA Mechanism To Regulate Protein Synthesis

New research has uncovered the mechanism used by cells to optimize the production of proteins in stressful situations by altering tRNA abundance. The regulating mechanism may play a vital role in preventing the proliferation of tumors.

Researchers from the Universitat Autònoma de Barcelona, and the Medical Research Council Cambridge (UK), for the first time, describe the mechanism used by cells to optimize the production of proteins in stressful situations by altering tRNA abundance.

Effects Of Microgravity On Gene Expression, Protein Content Of Human Chondrocytes

Going into space might wreak havoc on our bodies, but a new set of microgravity experiments may help shed light on new approaches for treating cartilage diseases on Earth. Scientists suggest that our cartilage tissue that serves as a cushion between bones might be able to survive microgravity relatively unscathed. The study was published in The FASEB Journal. 

Specifically, when in a microgravity environment, chondrocytes (a main component of cartilage) were more stable and showed only moderate alterations in shape and structure when compared to their Earthbound counterparts.

This was particularly the case for those also exposed to growth factors and specific nutrients. For those of us on the ground, the success of the growth factors and nutrients suggests that it might be possible to halt cartilage degradation or even reverse it with improved nutrition and/or new drugs.

Neuroscience Improves General Anesthesia

People sometimes mistakenly think of general anesthesia as just a really deep sleep but in fact, anesthesia is really four brain states unconsciousness, amnesia, immobility and suppression of the body's damage sensing response, or "nociception."

The study was published in Anesthesia & Analgesia. MIT neuroscientist and statistician Dr. Emery Brown and colleagues argue that by putting nociception at the top of the priority list and taking a principled neuroscientific approach to choosing which drugs to administer, anesthesiologists can use far less medication overall, producing substantial benefits for patients.

Association Between The Availability Of Hospital-Based Palliative Care And ICU Patients

For adult patients in the intensive care unit (ICU), the availability of hospital-based palliative care is not associated with in-hospital treatment intensity. The study was published in the Annals of the American Thoracic Society.

Researchers conducted a retrospective study of adult ICU patients to examine the correlation between the availability of hospital-based palliative care and treatment intensity. Data were included for 1,025,503 ICU patients in 151 hospitals.

Conflict Management Education In The ICU

The Intensive Care Unit is a stressful place, and conflicts invariably arise. To better understand the relationships between physicians, nurses, respiratory therapists, and advanced practitioners, researchers created a conflict management education intervention.

The study paid close attention to diagnosing the conflict type and cause, recognizing the internal dialogue, introducing conflict management modes used in conflict situations, and developing self and other awareness. The study was published in the journal CHEST.