All news from Anaesthesiology

Big Let-up In Obamacare Premiums

Millions of people covered under the Affordable Care Act will see only modest premium increases next year, and some will get a price cut. That is the conclusion from an exclusive analysis of the besieged but resilient program, which still sparks deep divisions heading into this year's midterm elections.

Methylation Of Enzymes Within Peptide Bonds

While chemical methylation of an amide bond uses a strong base to generate the imidate, OphA, the precursor protein of the fungal peptide macrocycle omphalotin A, self-hypermethylates amides at pH 7 using S-adenosyl methionine (SAM) as cofactor.

The peptide bond, the defining feature of proteins, governs peptide chemistry by abolishing nucleophilicity of the nitrogen. This and the planarity of the peptide bond arise from the delocalization of the lone pair of electrons on the nitrogen atom into the adjacent carbonyl.

End-of-Life Decision To Seek Advance Care

Former first lady Barbara Bush died on April 17 at the age of 92 in her home in Houston, Texas after making the decision to seek advanced care directive home care hospice, or comfort care, for her terminal illness.

The respected and beloved first lady was suffering from congestive heart failure and chronic obstructive pulmonary disease, and had decided a couple of days prior to her passing that she would “not seek additional medical treatment and will focus on comfort care.

New Study Transforming Tissue Cells Into Skin Cells

Researchers have transformed tissue cells into skin cells to help heal serious wounds, a technique that could revolutionise care for victims of burns and other severe injuries.

The research is the culmination of a decade of work and holds promise for a variety of patients, including those with serious burns or elderly patients with bedsores and other recurring lesions. The study was published in the journal Nature, involves a technology called “cell reprogramming” in which genes are inserted into cells to change them from one form to another.

Flight Brings Space Weightlessness To Earth

Not many aircraft captains give their passengers a rocket launch-style countdown before take-off, but this is no ordinary plane. For starters, everyone on board, apart from the crew, is a scientist and has passed a full medical check including a heart assessment. This is not a trip for nervous fliers.

The captain’s instructions refer to a manoeuvre so challenging it requires three pilots to be in the cockpit. The aircraft pulls up from a level flight into an incline at increasingly steep angles of 30, then 40 degrees. In the middle section, where the windows are blocked by a padded wall, everyone is either standing, sitting on the floor or lying down because the seats in this Airbus A310 have all been removed.