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Intra-Operative Hypotension Is A Risk Factor For Postoperative AKI

Impact of intra-operative fluid and noradrenaline administration on early postoperative renal function after cystectomy and urinary diversion. Acute kidney injury (AKI) is a potentially reversible and important contributor to postoperative morbidity and mortality. Its pathophysiology is likely to be multifactorial, with the inflammatory response and peri-operative hypovolaemia playing important pathophysiological roles.

The study was published in the European Journal of Anaesthesiology. Intra-operative hypotension is also a demonstrated independent risk factor for postoperative AKI, presumably through renal hypoperfusion and a subsequent reduction in medullary blood flow.

Indeed, it has been shown that most patients presenting with postoperative AKI have had at least one episode of peri-operative haemodynamic instability. Current evidence also supports a time dependent relationship between the duration of intra-operative hypotension and AKI.

Multidrug-Resistant HIV-1: Ibalizumab Reduces the Viral Load

Ibalizumab significantly reduces viral load in patients with multidrug-resistant (MDR) HIV-1, according to results from a single-arm, open-label phase 3 study. "Ibalizumab will provide an additional opportunity to achieve viral suppression for patients who have exhausted most currently available treatment options," Dr. Stanley Lewis from TaiMed Biologics, in Irvine, California reported.

Severe asthma: Insights Yeilds NET results

Of the more than 24 million people in the U.S. who have asthma, 10% have severe asthma—a form of the disease that does not respond to treatment. The immunological mechanisms underlying severe asthma and asthmatic lung inflammation are not well understood.

A new study by investigators from Brigham and Women's Hospital published this week in Science Immunology models allergic lung inflammation and provides new insights into how asthma develops and progresses, with important implications for the most clinically advanced drugs designed to treat severe asthma.

Outpatient Opioid Prescriptions Increased due to Inpatient Opioid Use and Insufficient Weaning Pre-discharge

Patients who receive an opioid for most of their hospital stay and patients who are still taking an opioid within 12 hours of being discharged from the hospital appear more likely to fill a prescription for opioids within 90 days of leaving the hospital, according to new research.

According to the University of Pittsburgh School of Medicine scientists who conducted the study, theirs is the first large-scale evaluation of the impact of in-hospital opioid prescribing on post-discharge opioid use.

Life-Threatening Respiratory Disease in Burn Patients: Three factors Aid in Prediction

For the first time, researchers have devised a model to predict burn patients who are most likely to develop life-threatening acute respiratory distress syndrome (ARDS). The prediction model includes three factors: the extent of the patient's inhalation injury, the percentage of the patient's body that was burned and whether the patient had high levels of a blood clotting protein called von Willebrand factor.

Deep Sea RV: New Habitat for Astronauts

Space RVs might sound like something the Jetsons would take on a cosmic road trip, but Lockheed Martin is going to make it a reality for astronauts venturing to Mars and beyond.

NASA gave the aerospace titan, along with Boeing, OrbitalATK, Bigelow Aerospace, Nanoracks, and Sierra Nevada Corp.’s Space Systems, a combined $65 million to prototype a deep-space habitat for its NextSTEP (Next Space Technologies for Exploration Partnerships) program by the end of the year.

New National Cervical Cancer Screening Recommendation, Study

The findings, published in the Journal of the American Medical Association (JAMA), were used to inform the U.S. Preventive Services Task Force, which published its updated recommendation on cervical cancer screening in the same issue of the journal.

The Task Force is an independent panel of experts that makes evidence-based recommendations on disease prevention. The Task Force also provides an annual report to Congress on the evidence base for clinical preventive services and recommends priority areas that deserve further examination.

ClariFix cryotherapy: New Treatment in Chronic Rhinitis

A new treatment that delivers a freezing or near-freezing temperature to the back of the nose of patients can offer relief to people suffering from chronic stuffy or runny nose, postnasal drip and cough. These symptoms result from persistently inflamed nose and sinuses, a condition known as chronic rhinitis.

Adherence To Guidelines For The Diagnosis Of Benign Paroxysmal Positional Vertigo

According to a new study, researchers estimate that adherence to guidelines for the diagnosis and treatment of benign paroxysmal positional vertigo (BPPV) is improving but remains suboptimal among ambulatory-care physicians.

They hope that primary-care and specialty physicians continue to improve in providing guideline-adherent care to persons with BPPV by refraining from ordering diagnostic imaging and prescribing anti-vertigo medications for the treatment of BPPV. The study was published in JAMA Otolaryngology-Head & Neck Surgery.