Tuberculosis is one of the world's deadliest infectious disease. Worldwide, there are still about 10.4 million cases of TB and 1.7 million deaths every year. One of the reasons it's been hard to bring the disease under control is that the drugs used to treat it require a gruelling regimen and can be toxic. This means people very often don't finish the course.
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Scientists have discovered that ketamine works as an antidepressant at least in part by activating the brain's opioid system. The research is believed to be the first to address how ketamine works in the human brain to provide relief from depression. The study was published in The American Journal of Psychiatry.
The previous decade has seen dramatic advances in the treatment of non-small cell lung cancer, as genes driving subtypes of the disease including EGFR, ALK, ROS1 and BRAF are paired with drugs that silence their action. However, a major genetic driver of non-small cell lung cancer is still without a targeted treatment.
The gene KRAS is known to be amplified in about 25% of non-small cell lung cancers (NSCLC) and despite over 10,000 studies related to KRAS listed in the PubMed database and just shy of 500 clinical trials including the search term KRAS at ClinicalTrials.gov, no successful drugs targeting KRAS are in clinical use.
Southern Africa has some of the highest rates of sexual assault in the world, with 20% of adolescent girls and boys reporting that they have been forced to have sex. In many cases, they are also the perpetrators: In one survey, 12% of boys and 5% of girls admitted they have forced someone else onto sex.
Backing a recent UK Parliamentary Committee report on e-cigarettes, Indian experts have contended that despite being 95% less harmful than tobacco cigarettes, they are often being overlooked as a smoking cessation tool.
According to the recent House of Commons Science and Technology Committee report, e-cigarettes should not be treated in the same way as conventional cigarettes.
Researchers explored clinical and genetic factors associated with atrial tachycardia (AT) after CHD surgery in infants younger than 1-year-old. They examined variants in the genes PITX2 and IL6, which are associated with postoperative atrial fibrillation in adults after cardiac surgery.
Arrhythmias disruptions in the rhythm of the heartbeat after congenital heart disease (CHD) surgery in children are common and contribute to increased morbidity and mortality. The investigators reported in the August issue of American Heart Journal that 15% of infants enrolled in the study experienced AT after CHD surgery.
AT was associated with the need for extracorporeal membrane oxygenation (ECMO) support and longer duration of ventilation, intensive care unit stays, and hospital stays. Variations in PITX2 and IL6 were not associated with postoperative AT.
Pfizer has agreed to pay German biotech firm BioNTech up to $425 million in an alliance to develop more effective influenza jabs, the latest among several major pharma companies to bank on a promising new genetic approach.