All news from Dermatology

Immunotherapy Combination With Pembrolizumab In Advanced Melanoma

The researcher has found that a treatment that uses a bacteria-like agent in combination with an immunotherapy drug could help some people with advanced melanoma, an aggressive form of skin cancer, live longer.

The research showed that using the immunotherapy drug pembrolizumab and the experimental agent SD-101, a sequence of nucleic acids that mimics a bacterial infection, altered the microenvironment around the tumor in a way that enabled the immune system to more effectively attack cancer. 

The research was an early-stage study, conducted to test the side effects and best dosage of a potential new combined therapy. The study was published in the journal Cancer Discovery.

Surveillance And Autopsy Characterization of Sudden Cardiac Death

Researchers identified all incident deaths attributed to out-of-hospital cardiac arrest (patients between 18 and 90 years of age in San Francisco County) based on autopsy, toxicology, and histology via medical examiner surveillance of consecutive out-of-hospital deaths.

A large percentage of deaths attributed to cardiac arrest is neither sudden nor unexpected. Deaths were assessed using the World Health Organization (WHO) criteria for sudden cardiac death(SCD), and the death certificates were reviewed for missed cases of SCD. The study was published in Circulation.

Astronauts Trying To Find Better Cancer Treatments In Space

With careful attention from an astronaut, a blood cell experiment may deliver improvements on cancer-fighting treatments. There's a lot of blood in space right now to be exact, there are a lot of endothelial cells that come from blood vessels.

Astronauts are helping study these cells aboard the International Space Station (ISS) as part of the Angiex Cancer Therapy trials, which NASA astronaut Serena Auñón-Chancellor introduced in a new video. The study was published in NASA.

Infectious disease outbreaks: Risk Increase with Rapid Development in Central Africa

The Central Africa region is experiencing rapid urbanization and economic growth, and infrastructure development. These changes, while generally positive and welcome, also make the region more vulnerable to explosive infectious disease outbreaks, according to an international group of scientists.

Writing in the New England Journal of Medicine, the authors, all of whom have field research experience in the region, note that efforts to build up the health care infrastructure in Central Africa are critically needed to mitigate or prevent a large outbreak of Ebola or another infectious disease in the region. 

Rabies Virus : Insight on its Disease Mechanism

To successfully infect its host, the rabies virus must move from the nerve ending to the nerve cell body where it can replicate. In a study published in the journal PLoS Pathogens, researchers from Princeton University reveal that the rabies virus moves differently compared to other neuron-invading viruses and that its journey can be blocked by a drug commonly used to treat amoebic dysentery.

Cell Connections Could Impact Circadian Rhythm

Researchers have developed a unified, data-driven computational approach to infer and reveal connections among cells in biological and chemical oscillatory networks. If you've ever experienced jet lag, you are familiar with your circadian rhythm, which manages nearly all aspects of metabolism, from sleep-wake cycles to body temperature to digestion.

Every cell in the body has a circadian clock, but researchers were unclear about how networks of cells connect with each other over time and how those time-varying connections impact network functions.

Researchers developed a unified, data-driven computational approach to infer and reveal these connections in biological and chemical oscillatory networks, known as the topology of these complex networks, based on their time-series data. The study was published in PNAS. 

Mortality In The US From Self-Injury Surpasses Diabetes

Researchers examined the self-injury mortality(SIM), a composite of all methods of suicide and estimated non-suicide deaths from drug self-intoxication, has surpassed diabetes as the seventh leading cause of death in the United States, prompting researchers to call for a new unified approach to SIM prevention.

It is time to end the siloed approach to prevention. Mortality in the United States from self-injury surpasses diabetes: a prevention imperative. The study was published online by Injury Prevention. They are so entrenched in separating suicide from a drug overdose or alcohol poisoning deaths that people can't wrap their heads around the idea that they are related.

Mental Wellness in College Sports, the Future Edge

While often glorified, these athletes also experience unique stressors that many of us may not understand. These include performance demands that require extensive mental precision, fatigue due to irregular and strenuous training and competitive schedules, ongoing scrutiny from others, separations from loved ones, and a culture supporting intense emotional expression.