Scientists have identified the function of a protein that has been confounding metabolism researchers for more than two decades. And it may have implications both for treating obesity and for understanding weight gain during pregnancy and menopause.
The protein, called the melanocortin 3 receptor (MC3R) maintains what Roger Cone, director of the U-M Life Sciences Institute, has termed "energy rheostasis," a poorly understood phenomenon in the field of metabolism research.
A lack of MC3R has almost no effect on mice under normal conditions. But when their metabolism is challenged, mice without this protein lose more weight when fasting and gain more weight when eating a high-fat diet, compared with normal mice.