According to the study, researchers explored whether activation of AMP-activated protein kinase (AMPK) could enhance osteoblast differentiation and mineralization through the induction of autophagy
Chemical investigation of the marine algal-derived endophytic fungus Aspergillus alabamensis EN-547 resulted in the isolation of 4-epi-seco-shornephine, a methyl ester, and 4-epi-seco-shornephine, A carboxylic acid, and two new secondary metabolites.
Magnum work with areas that straighten the innermost layer of the blood vessels, Johns Hopkins Medicine researchers say they have made great strides in understanding the biology behind pulmonary hypertension. The study published in Arteriosclerosis, Thrombosis, and Vascular Biology, suggests new targets for drug development for pulmonary hypertension.
A new study published in the Journal of Translational Medicine, suggests that chromosomal conformation signatures found in blood samples obtained in early rheumatoid arthritis could predict patients that will not respond adequately to 'anchor' treatment drug methotrexate with a high degree of accuracy.
A new comparative analysis published in the Journal of Clinical Oncology compares outcomes among younger men with prostate cancer who are treated with intensity-modulated radiotherapy (IMRT) against outcomes with two other technologies, proton therapy and stereotactic body radiotherapy (SBRT).
Scientists from the University of Melbourne have devised a method which might increase the sensitivity of magnetic resonance imaging (MRI) for the diagnosis of patients. The study was published in the journal Nature Communications.
A researcher from the University of Texas at Arlington is studying how blood flow and the contraction of cardiac muscle affect gene development that leads to ventricular chamber development in the heart. In future, the findings may lead to the identification of heart abnormalities that could then be treated with gene therapy.
Working with cells that line the innermost layer of the blood vessels, Johns Hopkins investigators say they have made a leap forward in understanding the underlying biology behind pulmonary hypertension, a dangerous type of high blood pressure in lungs that ultimately leads to right heart failure and death.
Over time, untreated depression changes to person's brain, according to brain imaging research published in The Lancet Psychiatry . This may dramatically affect how we understand mental illness and how it progresses over time.
A new study published in the American Journal of Physiology-Gastrointestinal and Liver Physiology explores newer, potentially safer therapies for treating chronic abdominal pain with lower risks of addiction and fewer side effects.
New clinical practice guidelines developed by the American Physical Therapy Association ( APTA ) to review the recent peer-reviewed literature and make recommendations related to the meniscus and articular cartilage lesions.
Repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for the treatment of diseases such as leukemia, provides a new therapeutic approach for ovarian cancer with mutations in the ARID1A gene, according to a study published in the journal Cell Reports.