All news from Anaesthesiology

Severe Dengue: Genetic variants make Asians and Europeans more Susceptible

As globalization and climate change spread tropical infectious diseases around the globe, not all populations have the same degree of susceptibility. Researchers identified gene variants common in people of Asian and European ancestry, making them more prone than those of African origin to developing severe dengue, which can lead to potentially fatal dengue shock syndrome. These results were published in the journal PLOS Neglected Tropical Diseases.

Quality of Generic Medicines and Perceptions

The objective is to understand people’s perceptions of generic medicines quality and assess how these perceptions affect access to medicines in government health facilities.

Researchers develop a framework to explain the role of trust in access to medicines and identify ways in which trust influences access to medicines in a local health system using focus group discussions (FGD) and in-depth interviews with patients and health workers. We also assess the quality of generic and branded equivalents of essential medicines for treating selected NCDs in a South Indian district.

Obesity: Resistance to Antiangiogenic Therapy Promoted

Obesity—which is already known to reduce survival in several types of cancer—may explain the ineffectiveness of angiogenesis inhibitors in the treatment of breast cancer.

A research team led by Massachusetts General Hospital (MGH) investigators describes finding that obesity and obesity-related molecular factors appear to induce resistance to antiangiogenic therapy in breast cancer patients and in two mouse models of the disease.

The report in Science Translational Medicine details specific obesity-related factors underlying that resistance and outlines potential therapeutic strategies that may overcome it.

GvHD Diagnosis And Scoring After HCT with the Aid of 'eGVHD App'

Allogeneic Hematopoietic Cell Transplantation (HCT) is a curative and established treatment approach for patients with hematological malignancies such as leukemia. However, graft-versus-host disease (GvHD), where the transplanted stem cells react against the tissues of the patient, is a major complication and often results in late morbidity and mortality, as well as in a reduction of quality of life. The accurate evaluation of this disease is thus of paramount importance to correctly evaluate and optimize transplantation outcome.

Urological Cancers: x5 Greater Suicide Rate in Patients

A major UK survey has shown that patients with urological cancer such as prostate, bladder or kidney cancer are five times more likely to commit suicide than people without cancer.

The analysis also shows that cancer patients generally are around three times more likely to commit suicide than the general population and that the proportion of attempted suicides which result in a completed or successful suicide was higher in cancer patients, with a higher proportion still in patients with urological cancers.