In this study, researchers examined the effectiveness of intraperitoneal instillation of high-volume low-concentration bupivacaine for postoperative analgesia in LC. Low-volume high-concentration bupivacaine irrigation of the peritoneal cavity has been reported to be ineffective for short-term analgesia after laparoscopic cholecystectomy (LC).
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A new study explained that researchers had examined early medieval migration in southern Germany and the peculiar phenomenon of artificial skull deformation. The transition from Late Antiquity to the Middle Ages in Europe is marked by two key events in European history, i.e., the fall of the Western Roman Empire and the migration into this Empire by various barbarian tribes.
The study carried out at UCL Institute of Ophthalmology has highlighted the potential of a targeted antisense oligonucleotide (ASO) therapy to treat Fuchs endothelial corneal dystrophy (FECD) patients with a mutation in the TCF4gene
The study evaluates the genetic defects of ciliary genes causing the loss of primary cilium in autosomal dominant polycystic (ADPKD). Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem disorder characterized by the formation of cysts in the kidneys and other organs. ADPKD affects more than 12.5 million people worldwide.
Approximately 50% of patients with ADPKD have the end-stage renal disease (ESRD) by 60 years of age. Dialysis and kidney transplantation are the only treatment options for patients with ESRD. The reason for the absence of targeted treatment is insufficient understanding of the molecular mechanism of cystogenesis. The primary cilium is a signaling organelle that extends from the surface of the plasma membrane of most mammalian cells.
In this study, researchers examined eczema affects about 17% of children in developed countries and is often the gateway to food allergy and asthma, initiating an "atopic march" toward broader allergic sensitization. There are treatments, steroid creams, and a recently approved biologic, but they are expensive or have side effects. The study was published in Science Immunology.
The U.S. Food and Drug Administration (FDA) has issued a letter to healthcare providers warning them that neurovascular embolization coils containing 304V stainless steel may increase image artifact when magnetic resonance angiography imaging is used to image a patient’s aneurysm after coiling.
Scientists at Southern Research are investigating how a mutated protein associated with prostate cancer plays a role in the development of the disease and whether it holds a key to better treatment outcomes. The study findings could lead to a new therapeutic target or a biomarker that predicts whether or not a certain course of treatment would benefit patients.
A new study, published in American Journal of Respiratory Cell and Molecular Biology (AJRCMB), suggest that ability of the body to produce lipids in the lungs could be enhanced to prevent the progression of pulmonary fibrosis, an ongoing process of scarring that leaves patients chronically short of breath, can progress in severity until the only course of treatment is lung transplant.
The palliative radiation therapy is used to relieve pain in patients with advanced lung cancer, but it has adverse effects on the esophagus which leads to symptoms like heartburn and difficulty swallowing.
Now Lawson Health Research Institute scientist Dr. Alexander Louie is testing new palliative radiation techniques to spare these effects on the esophagus and improve quality of life for lung cancer patients.
The study discovered that polyQ-ATAXIN1 and capicua complex could disrupt the expression of a number of genes in neurons in animal models of the disease. Patients with Ataxia type1 present with similar disruption of gene expression
Forensic Scientists have found a more accurate way to estimate an individual's age at death, based on the bone mineral density of the femur. The technique could be used to help identify human remains. The findings were published in the journal Science & Justice.
In the study, researchers assessed the visual impairment and intracranial pressure (VIIP) syndrome is a neuro-ophthalmologic condition described in astronauts returning from long-duration space missions. Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is characterized by a chronic elevation of intracranial pressure (ICP) in the absence of an intracranial mass lesion.