All news from Anaesthesiology

Genetic Defects Of Ciliary Genes Causing The Loss Of Primary Cilium In ADPKD

The study evaluates the genetic defects of ciliary genes causing the loss of primary cilium in autosomal dominant polycystic (ADPKD). Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem disorder characterized by the formation of cysts in the kidneys and other organs. ADPKD affects more than 12.5 million people worldwide.

Approximately 50% of patients with ADPKD have the end-stage renal disease (ESRD) by 60 years of age. Dialysis and kidney transplantation are the only treatment options for patients with ESRD. The reason for the absence of targeted treatment is insufficient understanding of the molecular mechanism of cystogenesis. The primary cilium is a signaling organelle that extends from the surface of the plasma membrane of most mammalian cells.

New Treatment For Eczema

In this study, researchers examined eczema affects about 17% of children in developed countries and is often the gateway to food allergy and asthma, initiating an "atopic march" toward broader allergic sensitization. There are treatments, steroid creams, and a recently approved biologic, but they are expensive or have side effects. The study was published in Science Immunology.

Pulmonary Fibrosis can be Reduced by Restoring Lipid Synthesis

A new study, published in American Journal of Respiratory Cell and Molecular Biology (AJRCMB), suggest that ability of the body to produce lipids in the lungs could be enhanced to prevent the progression of pulmonary fibrosis, an ongoing process of scarring that leaves patients chronically short of breath, can progress in severity until the only course of treatment is lung transplant.