All news from Anaesthesiology

More Realistic and Accurate Organs-on-Chips

In a step toward better diagnosis and treatment of digestive conditions, such as inflammatory bowel disease, scientists report in ACS Biomaterials & Engineering that they have developed a first-of-its-kind collagen-based membrane for use in microchips.

The membrane is more natural than others that are available, and it could allow organs-on-chips to more accurately replicate how healthy intestinal cells become diseased and how they react to drug treatments.

Schizophrenia Linked to Elevated Risk Of Breast Cancer

Patients with schizophrenia are considered to have many risk factors for the development of cancer. But the incidence of breast cancer in women with schizophrenia compared with the general population remains uncertain. A new study, published in JAMA Psychiatry, evaluate the link between schizophrenia and the risk of breast cancer, and found that incidence of breast cancer is higher among women with schizophrenia than the incidence among the general female population.

Read more at Speciality Medical Dialogues: Women with schizophrenia at higher risk of breast cancer – JAMA
Read more at Speciality Medical Dialogues: Women with schizophrenia at higher risk of breast cancer – JAMA
Read more at Speciality Medical Dialogues: Women with schizophrenia at higher risk of breast cancer – JAMA

Optical Tools: Metabolic Changes Linked to Disease detected

Metabolic changes in cells can occur at the earliest stages of the disease. In most cases, knowledge of those signals is limited, since we usually detect disease only after it has done significant damage.

Researchers have opened a window into the cell by developing an optical tool that can read metabolism at subcellular resolution, without having to perturb cells with contrast agents or destroy them to conduct assays. As reported in Science Advances, the researchers were able to use the method to identify specific metabolic signatures that could arise in diabetes, cancer, cardiovascular and neurodegenerative diseases.

Genetic Variation in Ribosomal RNA May Have Health Implications

The millions of cellular machines called ribosomes, which translate the genetic code carried by DNA into proteins, have long been thought to all be identical. A new study published in the journal Science Advances suggests that genetic variation in ribosomal RNA, the most essential component of the ribosome, may influence how much and which proteins are made. This finding could explain why ribosomal genes have been linked to developmental disorders.

Thirdhand Smoke Aggrevates Lung Cancer

Researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) identified thirdhand smoke, the toxic residues that linger on indoor surfaces and in dust long after a cigarette has been extinguished, as a health hazard nearly 10 years ago. Now a new study has found that it also increases lung cancer risk in mice.

Ebola: New Approach to Potentially Fight the Infecction

Researchers have shown an innovative antibody delivery method could be an effective way to prevent and treat Ebola infection. They demonstrated that delivering a monoclonal antibody gene to a cell through a viral vector — a process that bypasses the need for the host to generate a natural immune response — provided up to 100% protection against infection in mice. The mice expressed the antibody for more than 300 days.Their findings were published in the Journal of Infectious Diseases.