All news from Anaesthesiology

General Anesthesia, Opioid-Free Is Given For Spine Surgery Using Drugs

Researchers showed the case of a 65-year-old man undergoing a two-level lumbosacral posterior spinal fusion under general anesthesia using dexmedetomidine, lidocaine, and nitrous oxide, without the use of any intraoperative opioids and minimal opioids postoperatively for 24 h. To our knowledge, this is the first report documenting this anesthetic technique and its benefits through the first postoperative day.

In Circadian Rhythm, Sense of Smelling Differs

According to a new study, Researchers who are looking at how sleep may influence eating patterns in teens. A person's ability to smell may vary throughout the day in accordance with their circadian rhythm. It has always been apparent that some individuals have a better sense of smell than others, but a new study of 37 teens provides the first direct evidence that within each person, smell sensitivity varies over the course of each day. It tracks with the body's internal day-night cycle, or circadian rhythm. This study got published in Chemical Senses.

Thyroid Hormone Develops Angiogenesis In Liver Cancer

Thyroid hormone, 3, 3′, 5-triiodo-l-thyronine (T3), mediates several physiological processes, including embryonic development, cellular differentiation and cell proliferation, via binding to its nuclear thyroid receptors (TR). Angiogenesis is essential for human cancer development. The angiogenic process is balanced by the positive regulator, vascular endothelial growth factor (VEGF) and the negative regulator, thrombospondin-1 (TSP-1).

In A Helical Protein, Molecular Recognition and Packing Was Detected

A new study on Biomolecules has been demonstrated by showing the Folding of globular proteins entails a similar discrimination. To gain physical insight, we computed the binding affinities of helical structures of the protein Im9 in various native or nonnative configurations by atomic simulations, discovering that partial packing of the Im9 core is frustrated. This frustration is overcome when the entire core of the protein is assembled, consistent with experiment indicating no significant kinetic trapping in Im9 folding.

Treatment For Pharmacogenetics And Psoriasis Are Possible

According to researchers, Autoimmune disease, characterized by the host's immune response against self-antigens, manifests in more than 100 different types and affects more than 10% of the world's population, causing significant morbidity and high financial burden. Psoriasis (PS), is amongst the most common autoimmune diseases affecting approximately 2% of people globally, while it can also be a great model disease.

In A Developing Heart, Blood Flow Monitors The Maturation Of Heart Valves

Researchers from the Perelman School of Medicine at the University of Pennsylvania have found that the force, or shear, of blood flow against the cells lining the early heart valve sends signals for heart "cushion" cells to become fully formed valves. Congenital heart valve defects appear in 2 percent of all live births, making them the most common type of birth defect. This study has been published in Developmental Cell.

Childrens Injured From Window Blinds Were Send To Emergency Department Every Day

A study demonstrates that continued deaths from strangulation on window blind cords demonstrate urgent need for stronger safety standards. Almost 17,000 children under six years of age were treated in hospital emergency departments in the US for window blind-related injuries from 1990 through 2015, averaging almost two per day. While the majority of children were treated and released, there was about one child death each month — most from strangulation when a child became entangled by the neck in a window blind cord.

Nanoparticles Destroy Wide Group Of Viruses

An international group of researchers have designed new anti-viral nanoparticles that bind to a range of viruses, including herpes simplex virus, human papillomavirus, respiratory syncytial virus and Dengue and Lentiviruses. Unlike other broad-spectrum antivirals, which simply prevent viruses from infecting cells, the new nanoparticles destroy viruses. This study has been published in the journal Nature Materials.