A new report published in Molecular Cancer Research showed that adipocytes (fat cells) can absorb and metabolize the chemotherapeutic agent daunorubicin and thus decrease its efficiency and potentially be contributing to poorer treatment outcomes.
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Researchers found that tooth loss is linked to slower walking speed and poorer memory function in older people.The research team from University College London (UCL) in the UK analyzed data from over 3,100 adults aged 60 and over living in England. The study was published in the American Geriatrics Society.
Modern twin studies have shown how cells adapt to stressors — like water loss — by reprogramming their internal signaling networks. The studies describe mechanisms that cells use to send signals between cellular machinery and avoid cell death. The drugs that enhance the adaptation mechanisms could help cells ward off multiple diseases, including type 2 diabetes, studies published in Cell Reports and Molecular Cell suggests.
Sustainability and Transformation Partnerships, Clinical Commissioning Groups and primary care practices must all work together to improve outcomes for patients with Chronic Kidney Disease (CKD), according to the National Chronic Kidney Disease Audit published today. Recommendations include reviewing practice procedures and monitoring performance to help identify and actively manage patients with CKD.
Bass, Shen and their colleagues examined one such specialized machine, a protein from the common fruit fly, Drosophila melanogaster. Now that scientists know how the fly protein works, they may be able to use some of the same tricks to overcome viruses that cause human disease. The study findings were published in the journal Science
Through gene therapy, researchers engineered blood-forming stem cells (hematopoietic stem/progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected cells. These engineered cells not only destroyed the infected cells, they persisted for more than two years, suggesting the potential to create long-term immunity from the virus that causes AIDS.
In a new study published in the journal Cell Reports, the researchers have found a way to kill off the regulatory T cells, thus able to significantly increase the impact of the killer T cells. The study could pave the way for more effective cancer therapies.
Metformin exposure may affect fetal growth differently in normal-weight and overweight women with polycystic ovary syndrome (PCOS), according to a post-hoc analysis of data from a randomized clinical trial (RCT).
An “artificial pancreas” that monitors blood sugar and automatically delivers insulin may make it easier for athletes to manage type 1 diabetes and safer for them to participate in sports, a new study, published in Diabetes Care, suggests.
The study showed, for neonates born at a gestational age (GA) of 34 weeks or more, although inborn admission rates vary substantially across neonatal intensive care units (NICUs), the percentage of very ill admissions fails to explain this variation. The study was published in the JAMA Pediatrics
About 200 years ago, the Swedish scientist Jöns Jacob Berzelius discovered the trace element selenium, which he named after the goddess of the moon, Selene. Besides its industrial applications (chemical industry, production of semiconductors and toners), selenium is an essential trace element and indispensable for humans, many animals, and some bacteria. A team led by Dr. Marcus Conrad, research group leader at the Institute of Developmental Genetics (IDG), showed for the first time why selenium is a limiting factor for mammals.
Brazil has an extremely high rate of mortality from sepsis in intensive care units (ICUs), surpassing even mortality due to stroke and heart attack in ICUs. According to a survey conducted by researchers at the Federal University of Sao Paulo (UNIFESP) and the Latin American Sepsis Institute (LASI), over 230,000 adults die from sepsis in ICUs every year and about 55.7% of sepsis cases in ICUs end in death.