All news from Anaesthesiology

Interrupted Reprogramming: Progenitor-like Cells produced

A modified version of iPS methodology, called interrupted reprogramming, allows for a highly controlled, potentially safer, and more cost-effective strategy for generating progenitor-like cells from adult cells. As demonstrated in the journal Stem Cell Reports, the adult mouse respiratory tract cells called Club cells into large, pure populations of induced progenitor-like (iPL) cells, which retained a residual memory of their parental cell lineage and therefore generated mature Club cells. These cells showed potential as a cell replacement therapy in mice with cystic fibrosis.

Cancer mortality: Decades-long drop

The cancer death rate dropped 1.7% from 2014 to 2015, continuing a drop that began in 1991 and has reached 26%, resulting in nearly 2.4 million fewer cancer deaths during that time. The data is reported in Cancer Statistics 2018, the American Cancer Society's comprehensive annual report on cancer incidence, mortality, and survival. It is published in CA: A Cancer Journal for Clinicians and is accompanied by its consumer version: Cancer Facts and Figures 2018.

Biorelevant nanomaterials synthesis

Artificial polyelectrolytes can mimic the interactions of biological macromolecules such as nucleic acids, proteins, and polysaccharide-protein conjugates. Such synthetic polyionic complexes are expected to serve as novel platforms to stabilize and deliver drugs, proteins, or nucleic acids. In the journal Angewandte Chemie, Chinese investigators have introduced a versatile, commercially applicable preparation strategy of such nanomaterials with tunable morphology. The preparation of libraries of these low-dimensional bio-relevant nanostructures can be envisaged.

PlaqueTec Liquid Biopsy System Feasible to detect Biomarkers for CAD

New open?access article published in the 1 issue of the Journal of the American College of Cardiology [JACC] has revealed the feasibility and potential of the PlaqueTec Liquid Biopsy System™ (LBS) to detect biomarkers for coronary artery disease (CAD). The system reported results from the first?in?human studies of the LBS in detecting biomolecular gradients in diseased coronary arteries of symptomatic patients undergoing percutaneous coronary intervention (PCI) procedures.  

Discover the disorder first, biochemists suggest

The sequencing of the human genome has made it possible. The biochemists confirmed the cause of initially unclear symptoms of patients in Israel. Such a disorder is 'MPS III-E', originally also called 'Dierks's disorder' after its discoverer. The researchers are now presenting their analysis in the journal Genetics in Medicine, published by the Nature Publishing Group.

EPC Scale could be Used in General Medicine

In a new study, researchers have validated the 'Escala de Preocupación por el Cáncer – EPC' (an equivalent of the Cancer Worry Scale) to evaluate the fear of suffering from cancer. The study, published in Medicina Clínica, has revealed that the EPC is a valid and reliable scale for evaluating concern about cancer in healthy people.