All news from Anaesthesiology

Relationship between selenium levels and the risk of laryngeal cancer

According to this study, researchers conducted observational studies between selenium status and the risk of laryngeal cancer. Selenium is an essential trace element which is a cofactor for several antioxidant enzymes, and as a result, there has been much interest in the potential health benefits of adequate selenium status. Epidemiologic evidence is still emerging with respect to the full spectrum of the health benefits associated with selenium status.

CSA in a Human Model; Researchers Shown

In this study, researcher’s new experimental model of a CSA in a primate was reported; only the blood supply to the brain from the donor body was re-established; the spinal cord and the continuity of other organs were not restored. This experiment was designed to confirm that deep hypothermia can protect the brain and preserve brain function after re-warming during cephalic exchange.

Stress Linked to Early Development of Pancreatic Cancer

A new study published in the journal Cancer Cell has showed that stress accelerates the development of pancreatic cancer by triggering the release of "fight-or-flight" hormones. Beta-blockers–commonly used medications that inhibit these hormones–were found to increase survival in a mouse model of the disease. An additional analysis of patients with advanced pancreatic cancer revealed that those who were taking selective beta-blockers lived approximately two-thirds longer than those who were not taking the medications.

New Deep-Learning based Hematological Human Aging Clock Developed

In a research paper published in The Journal of Gerontology, the authors present a novel deep-learning based hematological human aging clock, a biomarker that predicts the biological age of individual patients. The developed model predicts the age better than models tailored to the specific populations highlighting the differences of subregion-specific patterns of aging. In addition, the developed clocks were shown to be a better predictor of all-cause mortality than chronological age.

Alzheimer’s Drug Turns Back a Cellular Clock

The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans. A new study, published in the journal Aging Cellreports that the drug, J147, binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, the study showed, it makes aging cells, mice and flies appear more youthful.

Specific Brain Circuit Controls Social Behavior

A new study published in Biological Psychiatry  has identified a key brain region of the neural circuit that controls social behavior. Increasing the activity of this region, called the habenula, led to social problems in rodents, whereas decreasing activity of the region prevented social problems. The improved understanding of altered brain function could help develop new targeted therapeutics for autism spectrum disorder.