According to a new study published in the issue of the New England Journal of Medicine, patients with monoclonal gammopathy of undetermined significance (MGUS) are at risk of progressing to multiple myeloma or a related cancer—even after 30 years of stability.
Patients with rheumatoid arthritis (RA) are at increased risk of serious infections, myocardial infarction (MI), and coronary heart disease (CHD), according to a study published in the Annals of the Rheumatic Diseases.
A collaborative study of a cancer target protein reveals unusual relation between binding site flexibility and drug-target lifetime. The results, published in Nature Communications, suggest a new strategy for drug discovery. The research was done in the framework of the Kinetics for Drug Discovery K4DD consortium, supported by the Innovative Medicines Initiative.
After years of studying the causes of asthma, a pediatrician-turned-public health sleuth thinks there's a way to substantially reduce its impact. But the approach faces a big hurdle: getting someone to pay for it, said Elizabeth Matsui, a physician and a professor at Johns Hopkins medical school in Baltimore.
A new study from The Ohio State University Wexner Medical Center examines what may cause chronic back pain in runners and the exercises to help prevent it.
In a new research, scientists have identified that older people walk at a slower speed and tire more quickly because of loss of strength and mass in leg muscles. Using computer simulations the team found that these physiological changes explain the slower walking speed preferred by the elderly, and that a focus on building up these leg muscles may be the only effective way to improve elderly walking. The study findings published in The Journal of Physiology.
According to a new study published in Pediatrics, adolescents with severe obesity who had bariatric surgery showed significant improvements in cardiovascular disease risk factors. Before bariatric surgery, 335 of the study participants had three or more defined cardiovascular disease risk factors. However, three years post-surgery only 5% of study participants had three or more risk factors; representing significant reduction in the overall likelihood of developing cardiovascular disease later in life.
Scientists from Michigan State University seek to investigate and potentially identify the brain mechanisms related to psychosis associated with schizophrenia. Researchers suspect these psychotic symptoms may be related to faulty signaling between regions of the brain that are involved in producing movement and regions of the brain involved in sensation.
A new study, published in the journal Proceedings of the National Academy of Sciences, described a machine learning algorithm that uses brain scans to predict language ability in deaf children after they receive a cochlear implant. This study's novel use of MRI and artificial intelligence to understand brain structure underlying language development has broad-reaching implications for children with developmental challenges.
A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans. The new vaccine completely protected 41% and reduced overall TB disease by 68% in vaccinated rhesus macaques, according to a study published as an Advanced Online Publication of Nature Medicine.
A recent study published in the journal Molecular Psychiatry explores how a protein named CK2 could play a key role in the formulation of new antidepressants that work more efficiently and faster for more people.