All news from Anaesthesiology

Four Building Blocks of Protein Make Up Energy For Humans

According to a new study, scientists have found the “Legos of life”, four core chemical structures that can be stacked together to build the myriad proteins inside every organism. After smashing and dissecting nearly 10,000 proteins to understand their component parts. The four building blocks make energy available for humans and all other living organisms. The study published in the Proceedings of the National Academy of Sciences.

Artificial Sweetener may Help Treat Aggressive Cancer with Less Side Effects

According to study published in ACS Journal of Medicinal Chemistry, artificial sweeteners are used in diet drinks and foods but also could someday be used as treatments targeting carbonic anhydrase IX (CA IX), a protein associated with aggressive cancers. Although several drugs have been approved that target similar forms of CA, they aren't selective and may cause side effects, including vomiting and fatigue.

Novel Approach to Treat Metastatic Pancreatic Cancer

In new research, scientists have tested a new precision medicine approach –OncoTreat therapy— to treat metastatic pancreatic cancer. Using the new approach, the team studied the RNA; the tissue-specific copy of a cancer cell’s DNA, rather than the DNA itself. This will give a much more accurate picture of the genetic programs operating inside a tumor that enable its survival.

Scientists Identified Molecular Roots of Genetic Lung Disorder

Most people with lung disease carry mutations in one of the genes that build the proteins that form molecular motors inside cilia. A single misshapen piece of protein can make the whole machine grind to a halt. But a few people have errors in proteins that are not part of the motor. Researchers at Washington University School of Medicine in St. Louis report they have solved that puzzle: The nonmotor proteins are like factory workers who put the motor together. Mutations cause these proteins to assemble the motor incorrectly.