All news from Anaesthesiology

APRV Versus Assist Control for ARDS; Study plans

A recently demonstrated randomized trial compared APRV versus the current standard of care, low-tidal-volume ventilation (LTV). Although many consider APRV to be a "rescue mode" for refractory hypoxemia, others argue that it minimizes ventilator-induced lung injury and maintain that APRV should be the primary mode of ventilation for patients with ARDS. This study was published in The American Journal of Respiratory and Critical Care Medicine. 

Strategies for in-flight physiological events such as hypoxia

A new Research using a new skill, Navy Aerospace Medical Institute (NAMI), a detachment of Navy Medicine Operational Training Center (NMOTC) investigated that could potentially become an early-warning signal to military pilots who are experiencing inflight physiologic events such as hypoxia.The senior medical officer of Naval Aviation Schools Command (NASC), who coordinates all NAMI research, is working with new Electroencephalogram (EEG) technology for use in hypoxia detection. 

Study Investigates The Fruit Fly To Understand The Human Brain

Researchers at Stanford established a direction by making a detailed cell-by-cell gene blueprint of the fruit fly's olfactory neurons. Scientists have been working to zoom in and identify how brain circuits form so they can learn to rewire troublemaking neurons. The human nervous system is like a complex circuit board. When wires cross or circuits malfunction, conditions such as schizophrenia or bipolar disorder can arise. Their study has been published in Cell.

A Key Protein Holds Clues for Better Drug Design

Scientists have examined deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases. A protein called A2A adenosine receptor (A2aAR), is a member of the G-protein-coupled receptor (GPCR) family, which are the targets of roughly 40 percent of all approved pharmaceuticals.

The new, more detailed image of A2aAR's signaling mechanism reveals key parts of its inner workings, including an amino acid that acts like a "toggle switch" to control signaling across the cell membrane. This study was published in the journal Cell.

IBD: Steroid Use may Increase Thromboembolism Risk

According to a study published in the Journal of Crohn's and Colitis, steroid therapy is associated with an increased risk of venous thromboembolic events in patients with inflammatory bowel disease (IBD), but biological therapy is not . The risk of venous thromboembolism (VTE) is 1.5- to 3-fold higher in IBD patients, compared with non-IBD controls, with most events occurring during acute flare-ups of the disease.