A new study published in the journal Cancer Cell has showed that stress accelerates the development of pancreatic cancer by triggering the release of "fight-or-flight" hormones. Beta-blockers–commonly used medications that inhibit these hormones–were found to increase survival in a mouse model of the disease. An additional analysis of patients with advanced pancreatic cancer revealed that those who were taking selective beta-blockers lived approximately two-thirds longer than those who were not taking the medications.
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Researchers from Osaka University have developed new green fluorescent protein (GFP) that could withstand low pH environment for imaging of acidic organelles. The findings were published in Cell Chemical Biology.
In a research paper published in The Journal of Gerontology, the authors present a novel deep-learning based hematological human aging clock, a biomarker that predicts the biological age of individual patients. The developed model predicts the age better than models tailored to the specific populations highlighting the differences of subregion-specific patterns of aging. In addition, the developed clocks were shown to be a better predictor of all-cause mortality than chronological age.
The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans. A new study, published in the journal Aging Cell, reports that the drug, J147, binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, the study showed, it makes aging cells, mice and flies appear more youthful.
A new study published in Biological Psychiatry has identified a key brain region of the neural circuit that controls social behavior. Increasing the activity of this region, called the habenula, led to social problems in rodents, whereas decreasing activity of the region prevented social problems. The improved understanding of altered brain function could help develop new targeted therapeutics for autism spectrum disorder.
In the current issue of the Journal of the Academy of Nutrition and Dietetics, healthcare experts have focused on hospitalized patients with malnutrition in the US and presented data elucidating the extent of the serious healthcare issue.
Genetic differences between different strains of the same pathogenic bacterial species appear to result in widely varying immune system responses, according to new research published in PLOS Pathogens.
According to a new study, while the risk of pregnancy is low after female sterilization procedures, 60% of pregnancies that do occur result in a live birth. The study was published in the Obstetrics & Gynecology . Researchers looked at close to 1,000 pregnancies after failed outpatient and surgical sterilization procedures.
The calcium phosphate cement flows into the spongy inside portion of the bone , filling in microfractures and other damaged areas, and it hardens in about 10 minutes' time. The cement braces the bruised or injured joint bone from the inside, and eventually is replaced by new bone as part of the body's natural healing process.
In this study, researchers declared the SHEA Guidelines Committee, comprised of experts in infection control and prevention, developed the recommendations based on available evidence, theoretical rationale, practical considerations, a survey of SHEA members, author opinion, and consideration of potential harm. This study got published in Infection Control and Hospital Epidemiology.
UCLA researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains and, in some cases, set the stage for several brain disorders that appear later in life.